Splenomegaly

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splenomegaly

[‚splē·nə′meg·ə·lē]
(medicine)
Enlargement of the spleen.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Splenomegaly

 

in medicine, the enlargement of the spleen. Splenomegaly occurs with diseases of the spleen (tumors, cysts, abscesses), with general infections (sepsis, malaria, typhoid fever, typhus), with blood diseases (leukoses, lymphgranulomatos-es), and with liver diseases. The spleen is examined by palpation while the individual is lying on his side; it will not be felt if its size is normal.

Splenomegaly is often the first manifestation of blood disease. In such cases, splenic puncture is performed in order to make an accurate diagnosis. With chronic leukoses, the spleen may occupy most of the abdomen and weigh as much as 8 kg. Splenomegaly is accompanied by disruption of breathing, blood circulation, and the functions of adjacent organs, including the stomach, intestine, and left kidney. Disturbances of splenic blood circulation (thromboses), suppression of hematopoiesis (hypersplenism), and other complications may also occur. The condition is treated by surgically removing the spleen (splenectomy), by irradiating the spleen with gamma rays, and by administering cytostatics and corticosteroids.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
A search of the literature revealed scant testing of the alleged association of acute splenitis with systemic infection and no criteria for diagnosing acute splenitis.
The concept of acute splenitis as a postmortem marker for systemic infection has been used in various studies despite a lack of criteria.
Therefore, the major histologic findings were hepatic necrosis, nephrosis, and splenitis, with intranuclear inclusion bodies.
Mild-to-moderate myocarditis, hepatitis, splenitis, and interstitial nephritis were also observed in the birds.
Merogony may result in chronic active hepatitis as well as interstitial myocarditis, myositis, splenitis, nephritis, and encephalitis.
Other microscopic abnormalities included splenitis marked by histiocytosis and plasmocytosis, as well as acute hepatitis with leukocytosis and hemosiderosis in hepatocytes and Kupffer cells.
Predominate lesions were a moderate to severe hepatitis with diffuse single-cell necrosis of hepatocytes and a splenitis characterized by necrosis of cells surrounding the sheathed arteries.
In addition, marked necrotizing splenitis and pulmonary hemorrhage were present.
Other than the 2 isolated findings of adenoviral splenitis and bacterial pneumonia and evidence of parasitism, avian pox, and chronic enterocolitis, no other significant disease was evident histologically in this group of 10 chickens.