subunit vaccine

(redirected from split-virus vaccine)
Also found in: Medical.

subunit vaccine

[‚səb‚yü·nit vak′sēn]
(immunology)
A type of noninfectious vaccine that consists of immunogenic viral proteins stripped free from whole virus particles, then purified from other irrelevant components, thereby reducing the risk of adverse reactions and residual infectious virus.
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References in periodicals archive ?
A candidate reassortant vaccine virus, derived from the A/ California/7/2009 (H1N1)v virus as recommended by the World Health Organization, was used to produce a monovalent, unadjuvanted, inactivated, split-virus vaccine for Australia (2,3).
Another trial was performed with 300 healthy participants 18-40 years of age, in which aluminum hydroxide adjuvant was used with similar split-virus vaccine (17).
In persons previously exposed to influenza disease or vaccination, placebo-controlled studies show similar rates of systemic reactions, such as fever, when split-virus vaccine is compared with placebo.