Dai et al., "Silibinin in vitro protects A549 cells from staphylococcus aureus-mediated injury and in vivo alleviates the lung injury of staphylococcal pneumonia
," Planta Medica, vol.
Before then, Harley's death had been put down to staphylococcal pneumonia
and no action was taken.
aureus sepsis 14 (95% CI 13-16) cases per 100,000, and staphylococcal pneumonia
5 (95% CI 4-6) cases per 100,000.
Treatment with intravenous linezolid and clindamycin was immediately started because the severity of the patient's condition and the isolation of Gram-positive cocci in the sputum supported the clinical suspicion of community-acquired staphylococcal pneumonia
. Nevertheless, the patient worsened and became hemodynamically unstable requiring intubation and vasopressors.
Given these conflicting reports, we investigated the immunomodulatory role of staphylococcal PAMPs in immune responses elicited by SSAg during TSS and in staphylococcal pneumonia
. Our studies, which used the robust HLA class II transgenic mouse model, showed that staphylococcal PAMPs do not suppress SSAg-induced T cell proliferation, do not dampen SSAg-induced systemic inflammatory response, and fail to protect from SSAg-induced TSS or staphylococcal pneumonia
Lastly, neutropenic patients are at high risk of developing fungal and staphylococcal pneumonia
in addition to pneumonias caused by the common pathogenic organisms alluded to above.
A 25-year-old male with history of intravenous drug abuse was referred to us for failure of clinical and bacteriological improvement despite 10 days of aggressive treatment for community acquired staphylococcal pneumonia
. During these 10 days he had received two uneventful suxamethonium-facilitated rapid sequence intubations on days 1 and 5, and short periods (<24 hours) of invasive mechanical ventilation.
He later died at Alder Hey Children's Hospital in Liverpool from staphylococcal pneumonia
, an antibiotic-resistant form of MRSA.
He then contracted an aggressive form of MRS A, staphylococcal pneumonia
, which was resistant to antibiotics, which killed him more than a month later.
This was a 4-year-old boy who was comatose at presentation, with bilateral hip sepsis and a severe staphylococcal pneumonia
. He died of overwhelming sepsis on day 4 in the ICU after drainage of both hips.
The presence of preceding staphylococcal skin disease among persons with staphylococcal pneumonia
has been described previously during an influenza pandemic (10).
proved fatal to more than a quarter of patients who contracted the infection, normally after entering hospital suffering from influenza.