stereoselectivity


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stereoselectivity

[¦ster·ē·ō·si·lek′tiv·əd·ē]
(biochemistry)
The selectivity of a reaction for forming one stereoisomer of a product in preference to another stereoisomer.
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In addition, the cytotoxicity of 1 and 2 was evaluated, 1 exhibited relatively better performance against A549 cell than 2, and also indicated apparent stereoselectivity as a result of stereo-configuration at the C24 position [12].
At the other end of the spectrum, traditional batch equipment is limited when cryogenic conditions are necessary, for example when stereoselectivity needs to be controlled, or to protect unstable intermediates.
Several attempts have been made to improve stereoselectivity utilizing chiral isocyanides and chiral cyclic imines [7-13].
In addition, this CoQ10 production methods further lacks stereoselectivity, which makes it difficult to segregate optimal isomers.
[31.] A.V.Demchenko, Handbook of Chemical Glycosylation: Advances in Stereoselectivity and Therapeutic Relevance, Wiley-VCH, Weinheim, Germany (2008).
Spontaneous dehydrations to the enone were observed using proline as the chiral catalyst; however, stereoselectivity was very low.
Goldberg, "Tris (phenanthroline) ruthenium (II): stereoselectivity in binding to DNA," Journal of the American Chemical Society, vol.
Yamada, "Stereoselectivity and enantiomer-enantiomer interactions in the binding of ibuprofen to human serum albumin," Chirality, vol.
Several reasons could be provided for this observation: (1) DPPH and ABTS assays carried out in methanol and aqueous ethanol media, respectively; (2) different mechanisms related to the radical-antioxidant reactions; ABTS radical scavenging activity is a single electron transfer reaction, while the DPPH radical scavenging assay transfers hydrogen atom or electrons [41]; (3) stereoselectivity of the radicals or the solubility of wheat extracts in different estimating systems [42].
Stereoselectivity characteristics and mechanisms of epidermal
Sanofi was the rare case in which the enantiomers ultimately patented exhibited "absolute stereoselectivity"--one isomer was responsible for all the therapeutic activity and the other was responsible for all the neurotoxicity.