stop codon


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stop codon

[′stäp ′kō‚dän]
(genetics)
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Mechanisms of pertactin deficiency and characteristics of Bordetella pertussis isolates from pertussis epidemics, Australia, 2013-2017 * Prn deficiency Position in prn mechanism ([dagger]) prn allele type IS481F 1613 prn2 IS481R 1613 prn2 IS481F 1598 prn3 IS1002R 1613 prn2 Deletion -297 to 1325 Not determined ([double dagger]) Stop codon 223 prn2 Deletion 2020-2023 prn2 Prn deficiency Year mechanism State (no.
The majority of pathogenic variants cause the premature stop codon. It is probable that RNA transcripts from the mutant gene were missing as a result of nonsense mediated RNA decay and this caused the loss of protein.
Many of you may remember the triplet code "lookup tables" from some textbook, telling you how each of the 64 possible three-base DNA genome elements codes for one of the 20 amino acids, or one of the three STOP codons: TTT is phenylalanine, ATC is isoleucine, and so on.
This mutation led to a premature stop codon, which very likely resulted in a truncated protein or loss of protein production.
[9] published the case of a French family with 2 affected siblings with a T to G transversion in exon 3 that changed a leucine to a stop codon (L106X).
The start codon (ATG) and the stop codon (TGA) are indicated by the green triangle * and red circle * symbols, respectively.
Homozygote nonsense mutation causing premature stop codon (p.Y428*) in SLC29A3 gene exon sequencing was detected.
Exon deletion has also been useful in vivo in mdx mice, which have a premature stop codon in exon 23 of the dystrophin gene.
The complete ORFs have both the start codon and the stop codon. The incomplete ORFs lack the upstream end, the downstream end, or both ends in which case the ORF holds the whole fragments without starting codons or stopping codons [21, 22].
MLL2 and KDM6A mutations that are thought to be responsible for KS generally create an early stop codon and truncate the protein before it is functional.
A Q356X heterozygous mutation was found in exon 6 of the CYP11B1 gene, which has previously been described in patients with an 11-beta-hydroxylase deficiency, and an R384X heterozygous alteration was found in exon 7 that results in a premature stop codon, causing the formation of a truncated protein without biological activity (Figs.