As previously reported and as noted above, one patient on givosiran discontinued treatment due to an increase in alanine aminotransferase levels greater than 8 times ULN, a protocol-defined stopping rule
; this elevation did not meet Hy's Law and subsequently resolved.
Use the "butt-brush" effect: The "butt-brush" effect is an example of a stopping rule
- a cue in your environment that gets you to stop something.
The combination of (n,[s.sub.0]) is used to control simultaneously the two types of risks and can be regarded as a new stopping rule
They describe other prediction models for large crashes, including SothebyAEs stock price prediction model and Warren BuffettAEs ratio of the value of the stock market to the value of the economy; examine the positive effect of the Fed meetings and small-cap dominance; discuss the approaches of investor Marty Zweig in making buy/sell or entry/exit decisions in financial markets using Fed information; and consider smaller declines that are largely unpredictable but can be dealt with, the Shiryaev and Zhitlukhin stopping rule
model for exiting bubble-like markets, and how to include crash predictions made by these models as scenarios in stochastic investment models.
Regarding the betting strategy, we use the Kelly Criterion, which defines the optimal size of a series of bets that maximizes the wealth growth rate in the long run (Kelly, 1956), and a stopping rule
based on atypical positive returns (black swans), which are defined based on historical information.
In  for the stopping rule
according with the balancing principle error estimates and information complexity estimates are given within the framework of the same projection method with the modified Galerkin scheme as discretization.
Thus, failure to achieve at least 4% weight loss after 16 weeks on liraglutide constitutes what the Food and Drug Administration has called a "stopping rule
," meaning it's time to discontinue the drug.
FIGURE 3: NEURAL NETWORK Model Summary Training Cross Entropy Error 705.839 Percent Incorrect Predictions 37.6% Stopping Rule
Used 1 consecutive step(s) with no decrease in error (a) Training Time 0:00:00.50 Testing Cross Entropy Error 357.565 Percent Incorrect Predictions 41.1% Case Processing Summary N Percent Sample Training 503 68.1% Testing 236 31.9% Valid 739 100.0% Excluded 0 Total 739 Dependent Variable: Cat_of_Pref (a).
We describe this problem as MED (Minimum Expected Delay) and solve it based on the optimal stopping rule
A stopping rule
is a rule that parents follow in deciding whether or not to have another child (Keyfitz, 1968).
Similar to both the GA and the HGA, the whole process is iterated until some appropriate stopping rule
Te sampling process is continued stage by stage until a prespecified stopping rule