stratum corneum


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Related to stratum corneum: stratum granulosum, Stratum spinosum

stratum corneum

[′strad·əm ′kȯr·nē·əm]
(histology)
The outer layer of flattened keratinized cells of the epidermis.
References in periodicals archive ?
Even though the depth of the stratum corneum is basically around 20 um, the specific diffusional route of nearly all molecules passing through the skin is 400 um.
Ceramides play a critical role in this barrier function and in the retention of water by the stratum corneum.
Stratum Corneum: Stratum corneum is the outermost layer of the epidermis which is in direct contact with the external environment.
These symptoms persist for 1-2 weeks after treatment because it may take that long for the stratum corneum to regenerate and shed the foreign material.
Here emulgel could be prepared from selected oil on the term of solubility study of antimicrobial agent in them and emulsifier, so problem of solubility of drug can be almost overcome hence drug can be made available in solubilized form in emulgel, which can penetrate stratum corneum for drug action at viable soft tissue of skin.
The stratum corneum arises where keratinocytes lose their nuclei, flatten and become filled with keratin filaments that are highly organised and held in place by the protein filaggrin.
FLG has several site-specific functions governed by the program of epidermal terminal differentiation in which a number of proteases are involved, such as corneum trypsin- and chymotrypsin-like enzymes (stratum corneum tryptic enzyme/kallikrein 5 [KLK5] and stratum corneum chymotryptic enzyme/KLK7),[sup][9],[10],[11] channel-activating serine protease1 (CAP1),[sup][12] matriptase (coded by ST14),[sup][12] and cysteine protease caspase-14[sup][13] and their key protease inhibitor lymphoepithelial Kazal-type-related inhibitor (LEKTI) (encoded by serine protease inhibitor Kazal-type 5 gene/ SPINK5 ).
This occurs when the extreme heat of El NiNo depletes the water content of the stratum corneum, the outermost layer of the epidermis.
In particular explaining to parents that although structurally similar both the epidermis and, the stratum corneum, are 20% and 30% thinner than that of an adult, which makes infant skin more susceptible to skin problems (Stamatas et al, 2010).
Over the subsequent decades, the role of the stratum corneum in maintaining optimal skin hydration and preventing excess TEWL has been further studied, understood, and appreciated.
The stratum corneum serves as a physical barrier against percutaneous penetration of chemicals and microbes (Madison, 2003).

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