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open sore or circumscribed erosion, usually slow to heal, on the skin or mucous membranes. It may develop as a result of injury; because of a circulatory disturbance, e.g., in varicose veins or after prolonged bed rest; or in association with such diseases as tuberculosis, syphilis, or leprosy. Corneal ulcers, which result from infection, allergy, or foreign objects in the eye, can cause visual impairment if not treated promptly. Some ulcers may develop into cancer. The underlying cause must be treated as well as the ulcerous lesion.

Peptic ulcer occurs in the mucous membrane of the intestinal tract. An estimated 90% of peptic ulcers are caused by infection with a bacterium, Helicobacter pylori, strains of which promote the formation of ulcers by causing an inflammtory response in the cells of the stomach wall, making it more susceptible to the hydrochloric acid secreted by the stomach. Most commonly, it occurs in the stomach (gastric ulcer) or at the beginning of the small intestine (duodenal ulcer, the most common form) and causes abdominal pain, especially between meals.

Infection with the H. pylori bacterium, which is also associated with some stomach cancer, is very common, but not all strains promote the formation of ulcers. Approximately 50% of those over 60 in developed countries are infected; in developing countries the infection rate is much higher, and infection usually occurs earlier in life. Experts are as yet uncertain how the bacterium is spread. Around 20% of those infected develop ulcers. Peptic ulcer is found more frequently in men. Heavy aspirin or ibuprofen use and smoking increase the risk of ulcer development.

The connection of H. pylori infection with peptic ulcer was made in the early 1980s by Australian scientists Barry J. Marshall and J. Robin Warren. It previously was believed that peptic ulcers were caused by emotional stress, though since the early 1900s researchers had reported finding curved bacteria in the stomachs of dead patients with ulcers more often than in those without ulcers. Marshall and Warren were awarded the Nobel Prize in physiology or medicine in 2005 for their work. Treatment changed accordingly and now typically consists of antibiotics (such as clarithromycin or amoxicillin) plus metronidazole (Flagyl) and bismuth subsalicylate (e.g., Pepto-Bismol). For the relief of symptoms, drugs such as famotidine (Pepcid), cimetidine (Tagamet), and omeprazole (Prilosec) may also be used. Hemorrhage or perforation of peptic ulcers requires emergency medical treatment.

The full set of genes (genome) of H. pylori was determined in 1997. This achievement will help researchers design new drugs to treat and prevent diseases caused by the bacterium.

The Columbia Electronic Encyclopedia™ Copyright © 2013, Columbia University Press. Licensed from Columbia University Press. All rights reserved. www.cc.columbia.edu/cu/cup/
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a defect in the skin or mucous membrane resulting from tissue necrosis. Ulcers are frequently chronic in course and nonhealing, for example, trophic ulcers of the skin. They may be caused by prolonged mechanical (friction, pressure), thermal, chemical, and other actions on tissues, as well as by trophic disturbances of the nervous system, specific and nonspecific infections (tuberculosis, syphilis, leprosy, typhoid), and decomposition of a tumor. The development of an ulcer may also be fostered by metabolic disorders (for example, diabetes mellitus), chronic poisoning, vitamin deficiency, endocrinous disturbances, and exhaustion.

Ulcers vary in shape (round, oval, stellate), depth, and size. The base of an ulcer may be covered by granulations, a purulent deposit, or necrotic tissue. Deeply penetrating ulcers are dangerous because they destroy the walls of blood vessels and cause hemorrhages. If the course of the disease is favorable, the regenerative process is dominant and scarring occurs; however, recurrences are possible.

Treatment is directed toward curing the main disease. Physical therapy and any one of a variety of topical ointments and dressings may be prescribed. Surgery is required in refractory cases.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.


Localized interruption of the continuity of an epithelial surface, with an inflamed base.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.


a disintegration of the surface of the skin or a mucous membrane resulting in an open sore that heals very slowly
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
References in periodicals archive ?
The colonization and time of colonization onset were not associated with different stress ulcer prophylaxis (p=0.6 and p=0.07, respectively) (Fig.
Alternative to PPI's Sucralfate is widely a cytoprotective agent and has been listed as an acceptable prophylaxis for stress ulcer by practice guidelines with the caveat of slightly higher rate of clinically signicant gastric bleeding compared with H2 antagonists9,10.
Guidelines for stress ulcer prophylaxis by The American Society of Health-System Pharmacists (ASHP, 1999) do not recommend prophylaxis in patients at low risk for bleeding, such as the adult general medical and surgical patients with fewer than two risk factors.
90-100% 6 12% [4.97, 25.00] 60-89% 20 40% [26.73, 54.80] 30-59% 18 36% [23.28, 50.86] Less than 30% 6 12% [4.97, 25.00] Most common indication for prescribing acid suppressing drugs Acute gastritis 25 50% [35.72, 64.28] Stress ulcer prophylaxis 11 22% [11.99, 36.33] Along with NSAIDs 10 10% [10.50, 34.14] Others 4 8% [2.59, 20.11] Acid suppressing drug preferably prescribed PPI 46 92% [79.89, 97.41] [H.sub.2] receptor blocker 2 4% [0.70,14.86] Others 2 4% [0.70,14.86] Do you read the package insert of the acid suppressing drug before prescribing?
Care processes with the highest correlations (>0.80)--nutrition, weaning off ventilation, deep vein thrombosis prophylaxis, stress ulcer prophylaxis, BSL recording and management, and bowel activity--may also have good 'face validity' with experts (i.e.
Finally, there is no consensus, in literature, over the discontinuation of stress ulcer prophylaxis.
On the contrary, while stress ulcer models closely reflect the realities of the stressful human situation, chronic acetic ulcers often penetrate into the underlying gastric muscle layers and offer the opportunity to monitor the healing effects of new products on well-established gastric ulcer craters.
While the authors did an impressive job of highlighting the evidence on this issue, they missed an opportunity to stress the overuse of AST for stress ulcer prophylaxis--especially in the non-ICU setting.
We targeted disease management, process changes and the development of a nursing-focused approach to care, including daily multidisciplinary rounding, utilization of a "daily goals checklist," VTE and stress ulcer prophylaxis, implementation of the "Surviving Sepsis Campaign," an improved critical care triage system, evidence-based infection control initiatives, glycemic control, P & P's written for patient safety and an electronic medical alert for non-critical care patients developing sepsis.
Internal bleeding from a stress ulcer was detected and his family, including son Albert, who still lives in Newcastle, feared the worst.