The mice used in our experiments were confirmed as C57BL/6J substrain
mice by a genetic background identification of the samples [Supplementary Material 2 [SUPPORTING:4]].
BCG-related lymphadenitis is the most common complication of BCG vaccination. BCG regional lymphadenitis is related to either of the following: (a) host-related factors, i.e., very early age of the patient, congenital or acquired immunodeficiency; (b) factors related to administration, i.e., subcutaneous instead of intradermal, higher dose; or (c) related to vaccine strain, i.e., residual virulence of the BCG substrain
, type of vaccine, and viability of final vaccine product.
Interestingly, further-developed substrain
named stroke-prone SHR [SHR-SP], apart from higher BP [SBP of about ~240 mmHg], exhibits severe vascular damages and increased incidences of deaths from a stroke compared to SHRs .
To test this possibility, we treated three additional, commonly-used inbred mouse strains with glimepiride (8 mg/kg/day) for two weeks: C57Bl/6N (a related substrain
without the susceptibility to diabetes ), BalbC, and C3H mice.
Finally, in the vitiligo substrain
of C57BL/6J mice, a variant in the master pigmented cell transcription factor Mitf (Microphthalmia-associated transcription factor)  caused relatively late onset pigment dispersion and increased eye size, possibly due to increased [IOP.sup.82].
Conventional interpretation of relatedness based on rRNA gene sequence similarity suggests that the sBG is a substrain
Stamaril uses the same vaccine substrain
17D-204 as YF-VAX, and has comparable safety and efficacy (9).
As stated by the codirector, Center for the Deterrence of Biowarfare and Bioterrorism, microbial forensics provides "much greater detail to determine the precise strain and substrain
." (6) Using a greater level of detail, the source of the anthrax was eventually traced to a vat at the U.S.
perfectly matched a substrain
isolated from a human patient.
BCG immunotherapy for bladder cancer--The effects of substrain
The P8 substrain
(SAM-P8) of these mice has a markedly shortened life span when compared to the R1 substrain
(SAM-R1), which also shows a slower aging process .
Accordingly, a cut-off value of [greater than or equal to] 130 mmHg was chosen to indicate the presence of hypertension under our experimental conditions (e.g., substrain
used, age of the rats, or use of the low-stress rat holder).