Our initial approach applies our Cancer Subtype
Platform (CSP) to parse the complexity of tumor biology and generate genomic signatures.
Additionally, Chidamide is a new molecular entity with global patent protection developed by Chipscreen Biosciences, China's first international-recognised subtype
selective histone deacetylation enzyme (HDAC) oral inhibitor and a national class 1.1 drug.
This resulted in a change of the molecular subtype
from basal-like (from the immunohistochemistry result) to HER2 (from the CISH result).
This is important because patients with subtype
1, unlike subtype
2, often do not respond well to medications and develop strictures - extreme narrowing of the gut tube, requiring surgery once it develops.
Lymph node involvement, age, high histological grade, and large tumor size were significantly associated with a poor survival outcome among BCS., In our series, a significant association with tumor size ( P < 0.001), OS ( P < 0.001), and RFS ( P < 0.001) among BCS, in which TN subtype
were associated with a larger tumor size, poor OS, and RFS survival outcome which is in accordance with previous studies.,, Previous studies have also shown that LVI is an independent poor prognostic factor in patients with breast cancer.
The SVD subtype
, also called lacuna stroke, usually occurs due to the fibrinoid necrosis and lipohyalinosis of arterioles affected by hypertension-induced pathological processes.
In addition, sections with GIM were stained with alcian blue (pH 2.5) and periodic acid Schiff (PAS) to identify the GIM subtype
. Two experienced pathologists (HML and TSN), blinded to any clinical and endoscopic information, jointly examined all the specimens and reached a consensus.
LAA was the most common ischemic stroke subtype
in our study.
The maximum-likelihood phylogenetic tree of the hemagglutinin (HA) gene showed that the H9N2 subtype
virus from Burkina Faso belonged to the G1 lineage, which has remarkable zoonotic potential.
28, 2015, found that patients with the PPR subtype
had a better overall prognosis, compared with their counterparts with the other subtypes
Of 101 patients analyzed 28 (27.72%) patients achieved PCR, and 73 (72.27%) patients did not achieve complete response, the rate of PCR differed significantly among 4 molecular subtypes
. About 5.9% (1/17) achieved PCR in luminal A, 4.8% (1/21) had PCR in luminal B (HER 2 -ve type), 23.5% (4/17) in luminal B (HER 2 +ve type), 50% (8/16) achieved PCR in HER-2 over expressed type and 46.7% (14/30) had PCR in triple negative subtype