The [alpha]-difluormethylornithine ([alpha]-DFMO), which is the ornithine decarboxylase suicide inhibitor
, has been extensively used to study the effects of limiting polyamine synthesis in cell culture and in experimental animals (Poso and Pegg, 1982; Pegg, 1986; Grossie et al., 1987; Kogan and Hagedorn, 2000).
One strategy for circumventing beta-lactamase-mediated resistance has been to combine the beta-lactam drug with a molecule sometimes referred to as a "suicide inhibitor
."  These molecules bind with the beta-lactamase, preventing it from inactivating the antibiotic.