sulfenic acid


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sulfenic acid

[¦səl¦fen·ik ′as·əd]
(organic chemistry)
An oxy acid of sulfur with the general formula RSOH, where R is an alkyl or aryl group such as CH3; known as the esters and halides.
References in periodicals archive ?
The studentship will focus on the computational development of covalent inhibition strategies for sulfenic acid, sulfenyl amide, and S-nitrosylated cysteines.
The reversible formation of sulfinic and sulfenic acid maintains the redox state of the plasma to the moderate, unprolonged exposure to OS [62].
Inside the intact cells of an onion, a molecule called sulfenic acid precursor floats around the watery filler like a napping human in a lazy river.
However, in a series of studies aimed at clarifying the antioxidant activity of garlic-derived thiosulfinates similar to allicin (1), it was discovered that the active molecule able to trap peroxyl radical was not (1) itself, but the sulfenic acid that derives from its decomposition by Cope elimination (Scheme 5) [46, 47].
Typical 2-Cys Prxs (Prx1-Prx4) are active as dimers organized in antiparallel fashion: that is, the peroxidatic cysteine residue ([C.sub.P]) in the amino terminus of one subunit reacts with the hydroperoxides and the resulting Cp sulfenic acid forms a disulfide linkage with the sulfhydryl group of resolving cysteine residue ([C.sub.R]) in carboxyl terminus of another subunit [3].
Redox-active cysteine residues in protein are subject to more than one kind of modification, which include disulfide, glutathionyl, nitrosyl, or sulfenic acid modification [61, 62].
Garlic contains the compound allicin, which releases the powerful antioxidant sulfenic acid as it is broken down by the body.
The new method detects sulfenic acid in proteins-a tip off to early oxidative stress and to a specific protein modification associated with cell growth pathways.
During the decomposition of allicin, sulfenic acid is formed, which acts as a free radical scavenger.
Monosulfidic crosslinks are expected to decompose into sulfenic acid derivatives, which are postulated as powerful antioxidants (ref.
Susceptible cysteine residues in redoxsensitive proteins exist as a thiolate anion in a physiological pH and they can be reversibly oxidized by hydrogen peroxide to yield sulfenic acid (SO-).