, rod cells, chloride cells, and blood cells were frequently occurring.
The sensory cells are spindle-shaped with darkly stained nuclei and supporting cells
that are oval and more transparent (Crofts 1929, Bevelander 1988).
IHC: inner hair cell, OHC: outer hair cell, and SC: supporting cell
. Scale bars: 10 [micro]m.
Trying a new tactic, Andrew Groves of the House Ear Institute in Los Angeles and his colleagues isolated supporting cells
from the inner ears of newborn mice and put them in culture dishes.
In Putnam's approach, they deliver endothelial cells, which make up the vessel lining and supporting cells
. Their scaffolding carrier is fibrin, a protein in the human body that helps blood clot.
AstroRx is an innovative cell-based treatment for ALS, which consists of brain supporting cells
(astrocytes) designed to replace the astrocytes whose functionality was damaged in ALS patients.
Although the inner ear has an intricate structure and is multifunctional, its origin is quite simple, and both the hair cells and supporting cells
of the inner ear arise from common progenitor cells [1, 2].
The latest patent joins others that the company has already been granted in Israel and Europe, for its innovative way of producing supporting cells
in the central nervous system from stem cells -- including myelin-producing cells.
SYP is a glycoprotein present in synaptic vesicles in almost all neurons and it is used as an immunohistochemical marker for neuronal tissues (Smith et al., 1993) while, GFAP is a major intermediate filament found in glial cells (Eng et al., 1985) and it has been expressed in the supporting cells
of the olfactory epithelium (Kim et al., 2005).
Researchers can't yet reproduce the supporting cells
in the lab and so need to get those cells from embryos, Hayashi says.
Another promising approach is to directly reprogram supporting cells
, already present in the heart--for instance, fibroblasts (e.g., connective tissue)--and convert them into pacemaker cells to restore cardiac function.
Astrocytes are neural supporting cells
that have been shown to be involved in neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS).