Predicting sustained virological responses
in chronic hepatitis C patients treated with peginterferon alfa-2a (40 KD)/ribavirin.
Daclatasvir plus sofosbuvir, with or without ribavirin, achieved high sustained virological response
rates in patients with HCV infection and advanced liver disease in a real-world cohort.
The IFN- receptors are single-membrane spanning proteins and responsible for signal transduction by increasing binding of ligands.7 Many researchers assessed the amount of IFN receptors' expression and their significant role in response to IFN treatment and patients with sustained virological response
(SVR) were found to have significantly higher expression levels of IFNAR-1 a nd IFN AR-2 compared to non-sustained responders.8
Follow-up cohort studies of patients with chronic hepatitis C and advanced fibrosis undergoing antiviral treatment SVR Non-SVR Untreated N 110 193 48 HCC, n (%) 6 (5.4) 26 (13.4) 14 (29.1) Hazard ratio 1.0* 2.3 4.0 SVR = sustained virological response
; HCC = hepatocellular carcinoma.
Development of hepatocellular carcinoma in patients with chronic hepatitis C who had a sustained virological response
to interferon therapy: a multicenter, retrospective cohort study of 1124 patients.
(d) Sustained virological response
at 12 weeks (SVR 12): overall, all patients included in the study (excluding one expired) achieved SVR 12 irrespective of genotype or treatment regimen.
The overall sustained virological response
(SVR) on completion of treatment was 90 %.
Treatment was, as expected, highly effective, with more than 95% achieving sustained virological response
, even in F4 fibrosis or Child-Pugh B/C cirrhosis groups.
Sustained virological response
rates of the treatment regimen (PEG-IFN [alpha]-2A + RIB and PEG-IFN [alpha]-2B + RIB) were investigated according to the genotype sub-groups.
Risk of late relapse or reinfection with hepatitis C virus after achieving a sustained virological response
: a systematic review and meta-analysis.
found that the rate of sustained virological response
was 72% after the treatment of pegylated interferon plus ribavirin and that sustained virological response
was significantly associated with a decrease in the liver fibrosis index and an increase in the albumin levels and platelet counts.
In HCV-infected patients, the achievement of sustained virological response
(SVR) after treatment reduces the risk of progression to clinical decompensation or development of hepatocellular carcinoma in cirrhotic patients and can even result in histological improvement in those with less advanced fibrosis.