Fire found out that certain RNAs can switch genes
on and off, making the technique invaluable as a research tool alone and promising as a potential weapon against disease.
In order for epigenetic modifications to be most effective they should be reversible, so cells can switch genes
off and back on again when needed, such as when a person eats a sandwich and needs to make hormones to tell the brain that the stomach is full or to deal with the sudden influx of energy.
But we do know that a proportion of the remaining sequences are used to switch genes
'on' and 'off 'like the on/off switches on a radio.
The smallest unit of chromatin is the nucleosome acetylases switch genes
on by freeing DNA from tightly packed chromatin.
To switch genes
on or off, these molecules attach themselves to stretches of DNA.
Epigenetic targets, those are targets that modify either DNA or its histone packaging to switch genes
on or off, are of increasing interest in drug discovery.
The methylation of specific nucleotide bases in DNA often serves to switch genes
Using these parts, we built four sensors that can be encoded in the bacterium's DNA that respond to a signal to switch genes
on and off inside B.
Transcription factors are molecules that switch genes
on or off.
The research has shown that obesogens switch genes
on and off in the womb, causing stem cells to be turned into fat cells.
Within cells, these molecules switch genes
on or off.
The McKnight laboratory is focused on the regulation of transcription factors, the regulatory proteins that switch genes
on and off, at a biochemical level with keen attention to biological relevance.