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Having the ability to produce physiologic changes similar to those caused by action of the sympathetic nervous system.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a pharmacological substance whose action basically coincides with the effects of the excitation of the sympathetic nervous system, including the constriction of blood vessels and the dilatation of bronchi. Inasmuch as sympathomimetics act on adrenergic receptors, that is, on receptor formations sensitive to norepinephrine and adrenaline, they are conventionally called adrenomimetics.

Sympathomimetics may be direct or indirect. Direct sympathomimetics act directly on adrenergic structures; they include norepinephrine, adrenaline, and Adrianol (also called sympa-thol). Indirect sympathomimetics either promote the release or block the capture of a mediator; they include Tyramine, Phena-mine (also called amphetamine), ephedrine, and imizin (also called imipramine). Indirect sympathomimetics cause the quantity of a mediator to increase and thereby produce sympathomimetic effects.

In clinical practice adrenaline, norepinephrine, and Adrianol are used locally to constrict blood vessels during hemorrhaging. They are also used to increase arterial pressure in cases of collapse. Ephedrine is used to arrest asthma attacks and to constrict peripheral vessels (for example, it is applied directly to the nose in cases of a cold). Phenamine is characterized by peripheral sympathomimetic action—for example, it constricts blood vessels and increases systole. It also exerts a stimulating effect on the central nervous system and consequently is used to excite nervous activity. Imizin is pharmacologically an antidepressant and is therefore used in the treatment of nervous and mental disorders accompanied by depression.


Zakusov, V. V. Farmakologiia, 2nd ed. Moscow, 1966.
Anichkov, S. V. Izbiratel’noe deistvie mediatornykh sredstv. Leningrad, 1974.
Goodman, L. S., and A. Gilman. The Pharmacological Basis of Therapeutics, 3rd ed. New York-London-Toronto, 1965.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Indeed, in addition to their psychotropic effect, mediated mainly by CB1 and/or CB2 receptors in the brain, SCs have been shown to interfere with serotonergic and sympathomimetic neurotransmission, including induction of vasospasm, leading to a wide range of serious adverse reactions, such as kidney injury, pulmonary, gastrointestinal, neurological, and cardiovascular events [8, 18].
Apart from the expected sympathomimetic effects, on a high dose these compounds may work as hallucinogenic drugs due to their agonist effect of the 5-HT2A receptors.
Nuggent, "Sympathomimetic Syndrome, choreoathetosis, and acute kidney injury following "bath salts" injection," Clinical Nephrology, vol.
Keiser, "Effects of injected sympathomimetic amines on plasma catecholamines and circulatory variables in man," Life Sciences, vol.
Bisoprolol is a highly selective b-adrenoceptor antagonist whose selectivity to b1/b2 receptors is about 120: 1, without intrinsic sympathomimetic activity or membrane-stabilizing activity.
According to the company, oxymetazoline is a sympathomimetic agonist that is selective for the ?1A-adrenoceptor over other ?1-adrenoceptors and non-selective for the ?2-adrenoceptors.
(10) With this in mind and the fact that the medical fraternity seems to be particularly vulnerable to stimulant use, the aim of this study was to determine the prevalence and correlates of non-medical sympathomimetic use as well as subjective opinion on peer numbers using these drugs and university's attitude towards this use among a sample of undergraduate medical students at a South African university.
They concluded that these effects were due to the sympathomimetic activity of cathinone and were similar to the effects of amphetamine.
Methamphetamine is closely related to amphetamine and ephedrine (a mixed-acting sympathomimetic).
Lam described nadolol as a nonselective beta-blocker that "has no intrinsic sympathomimetic activity, little myocardial depressant activity, and does not cross the blood-brain barrier.
While the authors correctly draw distinctions between the clinical appearance of anticholinergic toxidrome and the sympathomimetic toxidrome commonly associated with cathinone ingestion we believe there are some additions that we can make; it is mentioned that a D.