Cochlear implantation may be considered, as in other children with syndromic hearing loss
and certain inner ear abnormalities, if the appropriate audiologic, psychosocial, and medical criteria are met.
Aminoglycosides appeared as a major modifier factor for the phenotypic expression of the A1555G mutation in the families with non syndromic hearing loss in studies carried out from China (88), as the penetrance on hearing loss was shown to increase with aminoglycosides (94).
This mutation was also identified in an Italian family with neuropathy, Parkinsonism and ototoxicity (100) and another Italian family with maternally inherited non syndromic hearing loss (101) and a Chinese subject with auditory neuropathy (102).
The prevalence and expression of inherited connexin 26 mutations associated with non syndromic hearing loss in the Israeli population.