It is the first synthetic chromosome
ever assembled based on a eukaryotic organism, which stores DNA in nuclei.
We have shown that yeast cells carrying this synthetic chromosome
are remarkably normal," he said.
" This is the first synthetic cell that's been made, and we call it synthetic because the cell is totally derived from a synthetic chromosome
, made with four bottles of chemicals on a chemical synthesiser, starting with information in a computer," said Venter.
"We call it synthetic because the cell is totally derived from a synthetic chromosome
, made with four bottles of chemicals on a chemical synthesizer, starting with information in a computer." The team has earlier chemically synthesized a bacterial genome, and has also transplanted the genome of one bacterium to another.
American Venter has created a synthetic chromosome
from lab chemicals which will be transplanted into a living bacterial cell.
It shows that our synthetic chromosome
is hardy, and it endows the yeast with new properties," Boeke added.
So it's a whole new paradigm, the first time we have a cell that is totally controlled 100 per cent by a synthetic chromosome
," the Independent quoted him as saying.
Neochromosome designs, builds and optimizes entire synthetic chromosomes
that augment a host cell's genetic information, analogous to upgrading a computer's operating system.
Surprisingly, the yeast cells still grew normally even though the synthetic chromosomes
were not exact copies of their natural counterparts.
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