systemic inflammatory response syndrome


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Related to systemic inflammatory response syndrome: septic shock

systemic inflammatory response syndrome

[si¦stem·ik in‚flam·ə‚tȯr·ē ri′späns ‚sin‚drōm]
(medicine)
The spectrum of elicited pathophysiologic changes (including blood clotting and changes in metabolism, heart rate, and respiration) resulting from excess production of inflammatory mediators (for example, histamines and leukotrienes), which orchestrate the process of inflammation through various processes.
References in periodicals archive ?
DX-88 is specifically engineered to be a highly selective, potent inhibitor of human plasma kallikrein, a key regulatory enzyme that is thought to play a role in systemic inflammatory response syndrome (SIRS) and associated complications such as blood loss.
Heparin-based coatings have been reported to decrease the risk of Systemic Inflammatory Response Syndrome (SIRS), by reducing complement activation and platelet adhesion.
Bacterial bioterrorism agents cause infections that lead to systemic inflammatory response syndrome (SIRS) and septic shock often resulting in multiple organ dysfunction syndrome (MODS).
DX-88 is also in a Phase I/II trial for the prevention of blood loss and effects of systemic inflammatory response syndrome in patients undergoing coronary artery bypass graft surgery.
The researchers found that despite women having a trend toward a lower incidence of severe sepsis, systemic inflammatory response syndrome and multi-organ dysfunction syndrome, there was no difference in mortality.
These will be targeted at systemic inflammatory response syndrome [SIRS], aging, and the performance-sport market.
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