Chemotherapeutic agents enhance cell migration and epithelial-to-mesenchymal transition through transient up-regulation of tNOX (ENOX2) protein.
2009) Effect of capsaicin on tNOX (ENOX2) protein expression in stomach cancer cells.
Down-regulation of tumor-associated NADH oxidase, tNOX (ENOX2, enhances capsaicin-induced inhibition of gastric cancer cell growth.
Tickers featured: AMGN, ANDS, AUXL, AVII, BIIB, CBST, CHIR, COLY, CYTK, DNA, ENCY, GENZ, GILD, GSK, IDIX, IMCL, ITMN, MICU, MNTA, NBIX, NUVO, NVS, ODAC, OSCI, OSIP, PANC, PFE, PGNX, RHHVF, TELK, TNOX
, TRMS, VRTX.
This overactive form of NOX, known as tNOX-for tumor-associated NOX-has long been assumed to be vital for the growth of cancer cells, because drugs that inhibit tNOX activity also block tumor cell growth in culture.
In studies of cultured cells and isolated membranes of cells, researchers found that black tea could inhibit tNOX activity at dilutions of one part tea to 100 parts of water.
Their studies, done with cultured cells and with purified NOX protein in solutions, found that EGCg was capable of inhibiting the tNOX activity of cancer cells at low doses-such as those that could be derived from drinking several cups of green tea per day-but did not inhibit the NOX activity of healthy cells.
Tickers featured: AMGN, ARDS, BGEN, CHIR, DNA, DSCO, ENCY, GILD, GSK, IMCL, INGN, ITMN, MAS, NVS, OSIP, RDS, TNOX
, TRMS, UTHR.
Tickers featured: AKSY, ALT, AMEV, ARIA, ASCO, AVII, AZN, BGEN, BMRN, CGPI, CPHD, CYPB, DNA, DYAX, ENCY, GENZ, GERN, GNLB, GNTA, INKP, ISIS, MEDI, MLNM, NVS, RGEN, RITA, SUPG, TNOX
Tickers featured: AMGN, BAY, BGEN, CBST, CVTX, DNA, ESPR, GENZ, ILXO, IMCL, MEDI, MLNM, NPSP, NVS, ONXX, OSIP, TNOX
Tickers featured: ABGX, AFFX, CLL, CRA, DNA, DYAX, GENZ, IDPH, IMCL, IMMU, IMNX, INCY, MDZ, MEDX, MYGN, NVS, ORCH, PDLI, PRCS, RIGL, SCIO, SRA, TNOX