tachyphylaxis


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tachyphylaxis

[‚tak·ə·fə′lak·səs]
(immunology)
Rapid desensitization against doses of organ extracts or serum by the previous inoculation of small subtoxic doses of the same preparation.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
As nonprandial GLP-1 receptor agonists have longer half-lives and prolonged action, the gastric emptying effect is reduced by tachyphylaxis and their influence on postprandial glycemia is thus diminished by comparison with prandial agonists [81-84].
Wong, "Tachyphylaxis after intravitreal bevacizumab for exudative age-related macular degeneration," Retina, vol.
The first response to octreotide administration is usually hyperglycaemia followed by a blunted effect after 48 hours (tachyphylaxis).
We think that this course was not associated with tachyphylaxis but might be related with starting therapy with a more aggressive disease and insurance issues because we could not perform regular DEX implants.
TAS2R activation promotes airway smooth muscle relaxation despite [beta] (2)-adrenergic receptor tachyphylaxis. Am.
In parallel, the innate repertoire (adhesion molecules, PRRs, innate receptors, etc.) is continuously changing through the degree of expression, tachyphylaxis, due to secondary molecular modifications (changes in glycosylation, glycation), and so forth, thus affecting the strength/quality of interactions and integrated signaling.
Over time, treatment becomes less effective, with treatment failure due to tachyphylaxis occurring after a few days.
"Top-up" doses of 50 to 100 mcg (up to 1000 mcg daily) of sc octreotide can be used when symptoms are not adequately controlled with the long acting SS-analogs or in the unusual event of tachyphylaxis. Recent studies have also demonstrated that symptomatic control may also be obtained by either increasing the frequency (every two or three weeks) or the dose of long acting SS-analog administration; doses as high as 120mg/month of octreotide LAR have been used without major toxicity [29-32].
One child woke up during surgery (ketamine tachyphylaxis) and 6 children had delayed anaesthetic reversal.
(8) The incidence of adverse events related to study drug decreased over the course of the study, and no tachyphylaxis was observed.