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Association between the E-26 transformation-specific related gene expression level and internal tandem duplication of the fms-related tyrosine kinase 3 gene
IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication.
Sequence analysis from two patients of the FLT3 mutant samples (Table 3), confirmed the presence of tandem duplication of different sizes (33bp and 78bp).
tandem duplications within lineages) do not appear to differ greatly in rate (27).
FLT3 internal tandem duplication (ITD) mutations were more frequent in patients with APL than in other AML subtypes (17.
The CYP superfamily is also an excellent group for studying the evolutionary mechanisms that create gene families; previous studies of" this group have provided clear examples of the molecular processes, such as tandem duplication and gene conversion, that are considered to be most important in gene family evolution (Fernandez-Salguero et al.
Employing this method, the study found and confirmed a number of interesting genomic features, including a 4kb error in one reference sequence, anchoring and gap sizing of four NGS contigs, identification of misassembled NGS contigs, differentiation of the two HLA-DRB1 variants, and definition of numerous structural variants, such as a 5kb insertion and 30kb tandem duplication.
sup][1] Here, we report a case of FLT3-internal tandem duplication (ITD)-positive AML, who developed subacute thyroiditis during treatment with sorafenib.
Internal tandem duplication (ITD) mutations result from the duplication and tandem insertion of a portion of the juxtamembrane region (exons 14 to 15) of the FLT3 wild-type gene and occur in 20 to 30 Percent of patients.