Prof Gerwert added: "We are now conducting in-depth research to detect the second biomarker, namely tau protein
, in the blood, in order to supply a solely blood-based test in future." This is such promising news.
ACI-35.030 is a potent liposomal anti-pTau active investigational vaccine designed to elicit antibodies against extracellular phosphorylated pathological Tau protein
, in order to prevent and reduce the spread and development of Tau pathology within the brain.
NFTs made up of aggregated tau protein
are a hallmark of several neurodegenerative diseases, including Alzheimer's disease.
The team, led by professors Mook In-hee and Lee Dong-young, said it found a way to forecast the deposition of tau protein
in the brain with a blood test.
At present, there are mainly beta-amyloid (A[sz]) theory, tau protein
theory, nerve, and blood vessel theory are some of these in the aspect of the interpretation to the nosogenesis of AD.
There are many different proteins, but one of the more important ones -- the one Akoury and his colleagues have chosen to devote their efforts to -- is the tau protein
. The group has found two substances that seem to be delaying the clumping of the tau protein
, which essentially means delaying the progression of the disease.
SAN DIEGO -- The apolipoprotein E e4 allele appears to help drive a key pathological process in Alzheimer's disease: deposition of hyperphosphorylated tau protein
One, amyloid beta, accumulates outside of brain cells; the other, called Tau protein
, collects within the cells.
Antibodies against a variety of neural antigens such as amyloid [beta] proteins and peptides (1-42), tau protein
, asialoganglioside [GM.sub.1], S100B, glial fibrillary acidic protein (GFAP), rabaptin-5 (rab-5), adenosine triphosphate synthase (ATP-synthase), myelin basic protein (MBP), and many others known as autoantigens in Alzheimer's disease (AD) are detected in the sera or cerebrospinal fluids (CSF) of patients with AD [2, 8].
The histopathological hallmarks of AD include extracellular deposition of amyloid-[beta] (A[beta]) plaques, formation of neurofibrillary tangles (NFTs) from hyperphosphorylated tau protein
, and neurodegeneration caused by progressive loss of neurons and their processes .
NFTs, which are made up of aggregated tau protein
, are a hallmark of several neurodegenerative diseases, including Alzheimer's disease.
Further, scientists are developing drugs to target tau protein
, which is the chief component of tangled bundles of fibers within the Alzheimer's brain, called tau tangles.