References in periodicals archive ?
Many details we could only guess at before, we can now see unambiguously, and we now have an understanding of where the different components of telomerase interact," said Juli Feigon, a professor of chemistry and biochemistry in the UCLA College and a senior author of the study.
Connections were also noted between telomerase mutations and a hereditary lung disease called idiopathic pulmonary fibrosis.
In the present study, an attempt was made to study telomerase activity and Bc1-2 concentration in HCC induced rats after treatment with platinum azidothymidine (Pt-AZT), a new synthetic platinum compound and to compare these effects with those of azidothymidine (AZT).
In most tissues, telomerase turns off during development, after which telomeres shorten and limit the number of times a cell can divide, eventually losing their capping function--similar to the shoelace tip falling off.
This spectacular finding of the family analysis prompted the scientists to also look for mutated telomerase genes in non-inherited (sporadic) melanoma, which is much more common than the familial variant.
Citation: "Comparative Analysis of Telomere Length, Telomerase and Reverse Transcriptase Activity in Human Dental Stem Cells;" Jeon, B.
Working with yeast cells, Chartrand and his team developed a way to add multiple fluorescent markers to the RNA component of telomerase without impacting its function.
Telomerase is a ribonucleoprotein complex, consisting of human transcriptase reverse transcriptase (hTERT), proteins (hTP1), and RNA template for telomeric DNA synthesis (hTERC) (3); this complex synthesizes telomeres and stabilizes their length.
Telomerase is an enzyme that controls the lengths of deoxyribonucleic acid (DNA) at the ends of chromosomes, called telomeres.
With regard to telomerase activity, MDSpatients with different FAB subtypes showed large heterogeneity in their telomerase activity levels.
Their research showed that, in some organisms, such as the single-celled pond dweller Tetrahymena, telomerase continuously replenishes the chromosome's telomeric tips.
Arguing in favor of the marketing of telomerase activators for nutritional use is William H.