Telomere


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telomere

[′tel·ə‚mir]
(cell and molecular biology)
A centromere in the terminal position on a chromosome.

Telomere

 

the terminal segment of a chromosome. When chromosomes become fragmented, as through the action of ionizing radiation, some of the fragments may reunite, but they never reunite along the telomere. Consequently, telomeres prevent the joining of other segments of chromosomes.

References in periodicals archive ?
Shortened telomeres may, for instance, be the link between not getting enough quality sleep and developing chronic health conditions.
Diet Quality Indices and Leukocyte Telomere Length among Healthy US Adults: Data from the National Health and Nutrition Examination Surveys (NHANES) 1999-2002.
[USA], Feb 28 (ANI): In a new, a research team from Instituto Gulbenkian de Ciencia (IGC; Portugal), led by Jose Escandell and Miguel Godinho Ferreira, discovered a key aspect of the regulation of telomeres aAC" structures that appear at the tips of our chromosomes.
Some researchers have speculated that the most pervasive anti-ageing effects of exercise may occur at the tips of our chromosomes, which are capped with tiny bits of matter known as telomeres. Telomeres seem to protect our DNA from damage during cell division but, unfortunately, shorten and fray as a cell ages.
Telomeres hold information about the path of a subject's health and may provide an important biomarker of aging.
For women, higher scores on each of the indices were significantly associated with longer telomere length.
"An individual's telomere length at birth is known to influence their risk for disease decades later during adulthood," says Tang, professor of Environmental Health Sciences at the Mailman School.
Investigators from the Perelman School of Medicine at the University of Pennsylvania found that stem cells in the muscles of muscular dystrophy patients may, at an early age, lose their ability to regenerate new muscle, due to shortened telomeres.
According to a study from Japan, alcohol can damage telomeres, the protective ends of our DNA; shortened telomeres are linked to cellular aging, and could also raise your risk for certain diseases.
Dr Kappei said, We are now actively pursuing the exact molecular mechanism through which ZBTB48 controls telomere length, and further looking into ZBTB48s role in various cancers, such as neuroblastoma, in which the gene is frequently deleted.
The Cardiff team analysed samples from 134 myeloma patients, 80 MDS patients and 95 AML patients to see whether telomere length influences survival in these blood cancers.