Telomere

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telomere

[′tel·ə‚mir]
(cell and molecular biology)
A centromere in the terminal position on a chromosome.

Telomere

 

the terminal segment of a chromosome. When chromosomes become fragmented, as through the action of ionizing radiation, some of the fragments may reunite, but they never reunite along the telomere. Consequently, telomeres prevent the joining of other segments of chromosomes.

References in periodicals archive ?
Active Ag-NOR occur in telomeric areas of the short arm in one large and three mediumsized submetacentric pairs of autosomes (Arslan et al.
While the "scabripinnis complex" has been characterized by a preferential centromeric and telomeric pattern of C-bands (Fernandes and Martins-Santos, 2005; Souza et al.
Additionally long arms of some chromosomes had telomeric heterochromatin bands (Fig.
In the first step, telomerase added telomeric repeats (TTAGGG) to the 3' end of biotin labeled synthetic P1-TS and P2, generating PCR products with the telomerase-specific 6 nucleotide increments.
The progressive loss of telomeric DNA in human somatic (stem) cells is believed to act as a tumour suppressor mechanism that limits clonal proliferation, to prevent clonal dominance and ensure a polyclonal composition of (stem) cells in large, long-lived multicellular organisms.
I proposed that the length of telomeric DNA, located at the ends of chromosomes consists of repeated sequences, which play a buffer role and should diminish in dividing normal somatic cells at each cell doubling.
Damage within telomeric regions remains unrepaired and this helps to explain why cells lose their ability to regenerate as they age.
A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends.
Telomerase activity using the telomeric repeat amplification protocol (TRAP) was done using the TRAPeze Telomerase Detection kit S7700 (Chemicon International, Inc.
The mechanism of formation is unclear, but involves the loss of varying extents of the telomeric ends of the p and q arms, followed by annealing of the "sticky" ends in order to prevent further loss of genetic material.
In this study, the molecular cytogenetic characterization of mitotic chromosomes of the Provence flat oyster or dwarf oyster, Ostrea stentina, was performed through Giemsa staining, chromosome measurements, in situ restriction endonuclease banding, C-banding, fluorescence in situ hybridization with major ribosomal RNA genes (ITS1), and telomeric sequence [(TTAGGG).

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