Teratogenesis


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teratogenesis

[‚te·rə·tō′jen·ə·səs]
(medicine)
The formation of a fetal monstrosity.

Teratogenesis

 

the development of monstrosities. Terato-genesis may result from such nonhereditary changes as impaired embryonic development—the joining of such paired organs as the eyes or the absence, underdevelopment, or excessive or abnormal development of organs. Teratogenesis may also result from hereditary changes, or mutations, for example, harelip, cleft palate, brachydactyly, hexadactyly, and impaired development of the genital system. A number of monstrosities have been produced experimentally, thus enabling scientists to understand better the causes of their origin. The study of teratogenesis is important in medicine, systematics, and selective breeding.

References in periodicals archive ?
Experimental evidence indicates that the expression of miRNAs is altered following exposure to alcohol during development, and this may be one of the mechanisms underlying alcohol-related teratogenesis (Sathyan et al.
Mechanisms of teratogenesis induced by organophosphorus and methylcarbamate insecticides.
In order to assess the effects of current PCB contamination on aquatic organisms, we are analyzing the development of the frog Xenopus laevis when exposed to control solutions, waters and aqueous sediment extracts from streams near the Monsanto site using both the standard Frog Embryo Teratogenesis Assay--Xenopus (FETAX) and extended incubations of frog embryos in control solutions and test samples.
Evidence for embryonic prostaglandin H synthase-catalyzed bioactivation and reactive oxygen species-mediated oxidation of cellular macromolecules in phenytoin and benzo[a]pyrene teratogenesis.
Women who are suffering from nausea and vomiting in pregnancy frequently do not seek or receive specific therapy out of concern over safety, yet such fear is often based on misinformation and misperceptions regarding teratogenesis.
Frog Embryo Teratogenesis Assay-Xenopus (FETAX) is a 96 hr bioassay used to determine the developmental toxicity of chemicals and mixtures in Xenopus embryos (ASTM, 1990).
KEY WORDS: AHR, cleft, mesenchyme, mouse, nasal epithelium, RAR, retinaldehyde dehydrogenase (RALDH), teratogenesis, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Frog Embryo Teratogenesis Assay-Xenopus (FETAX) was used to determine the developmental toxicity of pseudoephedrine and caffeine mixtures and to determine if synergism or antagonism occurs between the two.
The effect of brewed and instant coffee on reproduction and teratogenesis in the rat.
The importance of oxidative stress as a mechanism of teratogenesis is suggested by several animal studies (Fantel 1996).
The temperature threshold for human teratogenesis is 39.