teratogen

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teratogen

[tə′rad·ə·jən]
(medicine)
An agent causing formation of a congenital anomaly or monstrosity.
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It can be stated, that pregnant animal testing alone is not qualified to predict the teratogenic potential of new compounds Furthermore, there is an increased political and public demand to reduce the use of laboratory animals due to objections to experiments on living animals.
Given the consensus that the X-ray dose in routine diagnostic radiation is too low to cause severe teratogenic effects, this is an inappropriately high perception of the risks.
Hyperthermia is also recognized as being teratogenic in eutherian mammals, (21) the result of thermally induced apoptosis of cells during organogenesis.
The patient was informed about the teratogenic effects of the drug and counselled about complete abstinence while on therapy.
The CD-1 mouse is otherwise resistant to the teratogenic actions of prenatal ethanol exposure.
Reports found in RTECS provide users with the carcinogenic, mutagenic, and teratogenic effects of chemical substances on humans and various animal species.
The dangers of working during pregnancy are increased injuries to the mother, potential detrimental effects on the growth and development of the fetus, and the possibility of teratogenic (birth-defect causing) actions of workplace chemicals.
states during 20132015 found a pregnancy rate of 7.6% in 4,853 females aged 15-19 who were prescribed at least one of eight teratogenic medications, mostly labeled as category D or X: cyclophosphamide, enalapril, leflunomide, lisinopril, losartan, methotrexate, mycophenolate, and cyclosporine (category C).
A review of all concomitant medication should be done to exclude all potentially teratogenic drugs.
An in vitro assay using zebrafish (Danio rerio) embryo have been used in teratogenic screening and is considered as appropriate model of human cancers.