tetanospasmin


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tetanospasmin

[‚tet·ən·ō′spaz·mən]
(biochemistry)
A neurotoxin elaborated by the bacterium Clostridium tetani and which is responsible for the manifestations of tetanus.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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It is caused by tetanospasmin, a toxin released by clostridium tetani.1 Clostridium tetani, is a mobile gram-positive sporeforming obligate anaerobe with soil or dust as its natural habitat.
Tetanospasmin, for example, enters the motor nerves and surges back up them to the spinal cord where it inhibits motor nerve function.
Rather, the tetanus malady is caused by a neurotoxin ("tetanospasmin") that is produced by the bacteria after it is introduced to an oxygen-deprived setting (as in puncture wounds) and it begins to reproduce.
Tetanus is caused by clostridium tetani, which produces a powerful neurotoxin, tetanospasmin affecting the central nervous system.2 Patient develops frequent body spasms, locked jaw and dysphagia.3 Wide swings in blood pressure and heart rate are common secondary to autonomic instability due to disinhibited autonomic discharge.4-6 Neuronal binding of toxin is irreversible and clinical recovery follows the growth of new nerve terminals explaining the usual prolonged course of illness.7
Under anaerobic conditions, these spores geminate and elaborate tetanospasmin and tetanolysin.
[6] Two toxins are produced by the tetanus bacillus, namely tetanospasmin and tetanolysin.
Tetanus is a non-contagious acute infectious disease caused by exotoxins (tetanolysin and tetanospasmin) produced by Clostridium tetani.
tetani which produces exotoxins, tetanospasmin. In the present study, clinical signs are similar as described by Matthews (1999) and neutrophilia in hematological changes were in accordance with Srikanth et al.
However, no information was available about the production of tetanospasmin by the infecting strain.
Clostridium tetani produces the potent toxin tetanospasmin that causes painful muscular spasms and potentially respiratory failure in tetanus.
Tetanospasmin, for example, enters the motor nerves and travels back up them to the spinal cord, where it inhibits motor nerve function.
tetani produces tetanospasmin, a neurotoxin that disrupts nerve impulses to muscles.