tetanospasmin


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tetanospasmin

[‚tet·ən·ō′spaz·mən]
(biochemistry)
A neurotoxin elaborated by the bacterium Clostridium tetani and which is responsible for the manifestations of tetanus.
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6] Two toxins are produced by the tetanus bacillus, namely tetanospasmin and tetanolysin.
In severe cases the release of tetanolysin and tetanospasmin can lead to respiratory failure and hemodynamic instability associated with dysautonomia.
Tetanus is an acute, potentially fatal disease caused by Clostridium Tetani which produces a powerful neurotoxin tetanospasmin which affects the central nervous system.
However, no information was available about the production of tetanospasmin by the infecting strain.
Clostridium tetani produces the potent toxin tetanospasmin that causes painful muscular spasms and potentially respiratory failure in tetanus.
Tetanospasmin, for example, enters the motor nerves and travels back up them to the spinal cord, where it inhibits motor nerve function.
tetani produces tetanospasmin, a neurotoxin that disrupts nerve impulses to muscles.
tetani colonizes devitalized tissue, the exotoxin tetanospasmin is disseminated to inhibitory motor neurons, resulting in tetanus.