In addition, override of the G1/S, intra-S, G2/ M, and mitotic spindle checkpoints in Chk1-downregulated C10 cells lead to tetraploidy
, a sign of chromosomal instability.
In the pholcid Mesabolivar luteus, some diplotene cells appeared in pairs, and the authors also suggested that the organization of the testicular cells was responsible for this apparent tetraploidy
(Araujo et al.
On the other hand, tetraploidy
may have a direct role in tumorigenesis, as an intermediate state in the development of aneuploid cancers.
There were 13 T-ALL patients with successful karyotyping: 6 (46.15%) patients had normal karyotype and the main abnormalities were Dup21, del 6q21, der 13, dup 1, t(11;14), near tetraploidy
, and del 1.
Microsatellite evidence for tetraploidy
in invasive populations of the New Zealand mudsnail, Potamopyrgus antipodarum (Gray, 1843).
American and European researchers examine the role of homeostasis in carcinogenesis, the link between tetraploidy
and neoplastic progression, continuum models of mesenchymal cell migration, and diffusional instability as a mechanism of tumor invasion.
checkpoint and the suppression of tumorigenesis.
In our study, we established a double hyperdiploidy frequency, tetraploidy
in particular, in comparison with hypodiploidy.
This discrepancy is most likely due to the tetraploidy
of the zebrafish genome and compensation by redundant paralogs (Luo et al., 2001; O'Brien et al., 2004; Yan et al., 2005; Lister et al., 2006).
A reason for this higher variability could be the sour cherry tetraploidy
. Only the two varieties 'Garrafal' and 'Garrafal Negra' have some similarity of 0.49 (Fig.
Tetraploid hybrids are easier to produce, are more fertile and tetraploidy
may enhance intergeneric recombination as well as mitigate selection pressures, if any, that could operate against some combinations of chromatin from the two parental genera.
Structural rearrangements, monosomy X, triploidy, and tetraploidy
also were found.