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A hereditary form of hemolytic anemia resulting from a defective synthesis of hemoglobin: thalassemia major is the homozygous state accompanied by clinical illness, and thalassemia minor is the heterozygous state and may not have evident clinical manifestations. Also known as Mediterranean anemia.



(also thalassanemia), a familial hemolytic anemia, first detected in 1925 among inhabitants of the Mediterranean region. Thalassemia is caused by disturbances in hemoglobin synthesis.

References in periodicals archive ?
in 2007, thalassemia-specific consultation showed to be highly effective in reducing the birth rate of children afflicted with [beta] thalassemia major (14).
The aim of the study was to evaluate right and left ventricular systolic and diastolic function using MPI in young, asymptomatic children suffering from thalassemia major, for early detection of cardiac function impairment, preventing further cardiac damage by modifying disease progression and treatment.
Evaluation of the efficacy of chelation therapy with deferoxamine in patients with thalassemia major.
His past medical history was significant for thalassemia major, and he had received blood transfusions once every 3 to 4 weeks for the previous 3 years.
Not long ago, children born with thalassemia major seldom survived to the age of ten.
Children born with thalassemia major show symptoms of severe anaemia and cannot produce normal, adult haemoglobin.
One in 12 people in the UAE carry the thalassemia gene and those who are diagnosed with thalassemia major require not just specialist care, but also need to be treated with patience and compassion.
Novartis Oncology will also share updated efficacy data on ExjadeA (deferasirox) in transfusion-dependent thalassemia major patients with severe cardiac iron overload.