thalidomide


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thalidomide

(thəlĭd`əmĭd'), sleep-inducing drug found to produce skeletal defects in developing fetuses. The drug was marketed in Europe, especially in West Germany and Britain, from 1957 to 1961, and was thought to be so safe that it was sold without prescription. In 1961 an extremely high incidence of European babies born with malformed, shortened limbs was correlated with use of thalidomide by women in their first trimester of pregnancy. Before it was recalled from use the drug had caused the malformation of about 8,000 children throughout the world.

Thalidomide never entirely disappeared from use, however, and it was later found to benefit some leprosyleprosy
or Hansen's disease
, chronic, mildly infectious malady capable of producing, when untreated, various deformities and disfigurements. It is caused by the rod-shaped bacterium Mycobacterium leprae, first described by G.
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 patients. In 1998, after a complex safety monitoring system had been established to prevent further birth defects, thalidomide was approved for use in the United States for a complication of leprosy. The drug is also used to treat multiple myeloma, a cancer that affects the bone marrow.

thalidomide

[thə′lid·ə‚mīd]
(pharmacology)
C13H10N2O4 A drug used as a sedative and hypnotic; may produce teratogenic effects when administered during pregnancy.

thalidomide

supposedly harmless sedative resulted in disfigured babies. [Am. Hist.: Van Doren, 582–583]

thalidomide

a. a synthetic drug formerly used as a sedative and hypnotic but withdrawn from the market when found to cause abnormalities in developing fetuses. Formula: C13H10N2O4
b. (as modifier): a thalidomide baby
References in periodicals archive ?
To mark this 60th anniversary, Gary has joined forces with good friend Ricky Tomlinson in a bid to raise PS100,000 to make a film about their quest to put on a red carpet event that celebrates 60 years of achievements by victims of the Thalidomide drug.
Powell was Minister of Health when the thalidomide scandal came to light in the winter of 1961.
It has not compensated thalidomide survivors in the UK where the drug was approved by the Government and marketed by Distillers.
"The reason for creating the memorial was to ensure that the story of thalidomide would never be forgotten, and for this we need to pass the story on to younger generations.
Despite that the inhibition of NF-[kappa]B by PYR-41 and thalidomide was already documented [2-4], the effects of PYR-41 and thalidomide on myddosome formation are still to be elucidated.
Subject to FDA approval of Lannett's ANDA for Thalidomide, the company intends to launch its product under the terms of the license agreement, which are confidential.
The 2pm service is open to all and will culminate in a minute's silence, preceded by a role call of all those touched by the Thalidomide tragedy who have died in the past 12 months.
Thalidomide and a series of its analogs (2-5) are shown in Figure 2 and synthesized in a one-pot reaction (Scheme 1), using mild conditions and inexpensive reagents, under green (microwave) conditions with relatively high yields.
In Brasilia, thalidomide was prescribed for 10 AIDS patients (1.2% of all prescriptions) in 2001 while no prescription for AIDS was recorded in 2011/12 (Table 1).
"Although thalidomide disturbs the microenvironment of tumor cells in bone marrow, it disintegrates in the body.