thalidomide


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thalidomide

(thəlĭd`əmĭd'), sleep-inducing drug found to produce skeletal defects in developing fetuses. The drug was marketed in Europe, especially in West Germany and Britain, from 1957 to 1961, and was thought to be so safe that it was sold without prescription. In 1961 an extremely high incidence of European babies born with malformed, shortened limbs was correlated with use of thalidomide by women in their first trimester of pregnancy. Before it was recalled from use the drug had caused the malformation of about 8,000 children throughout the world.

Thalidomide never entirely disappeared from use, however, and it was later found to benefit some leprosyleprosy
or Hansen's disease
, chronic, mildly infectious malady capable of producing, when untreated, various deformities and disfigurements. It is caused by the rod-shaped bacterium Mycobacterium leprae, first described by G.
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 patients. In 1998, after a complex safety monitoring system had been established to prevent further birth defects, thalidomide was approved for use in the United States for a complication of leprosy. The drug is also used to treat multiple myeloma, a cancer that affects the bone marrow.

thalidomide

[thə′lid·ə‚mīd]
(pharmacology)
C13H10N2O4 A drug used as a sedative and hypnotic; may produce teratogenic effects when administered during pregnancy.

thalidomide

supposedly harmless sedative resulted in disfigured babies. [Am. Hist.: Van Doren, 582–583]

thalidomide

a. a synthetic drug formerly used as a sedative and hypnotic but withdrawn from the market when found to cause abnormalities in developing fetuses. Formula: C13H10N2O4
b. (as modifier): a thalidomide baby
References in periodicals archive ?
To begin with this flow of information, people potentially affected by Thalidomide now have a period of six months to officially request that they study whether their case is compatible with Thalidomide embryopathy.
Cyclophosphamide, chlorambucil, intravenous tacrolimus, mycophenolate mofetil and thalidomide have also been found to be effective in a limited number of patients refractory to other therapies.
The 2pm service is open to all and will culminate in a minute's silence, preceded by a role call of all those touched by the Thalidomide tragedy who have died in the past 12 months.
This retrospective case note review aims to describe the spectrum of ENL seen at HTD, the use of steroids and thalidomide in its management and the complications of their use.
To assess the robustness of the effect of thalidomide addition to the MP regimen and to explain the heterogeneity observed for the outcome of OS and PFS, additional sensitivity analyses were performed.
People who were affected by thalidomide are still fighting for recognition and compensation.
Most of the work on the efficacy of thalidomide and the analogues has been carried out in preclinical models.
Pauline had sacrificed marriage and children to pursue her career as a headteacher and in 1968 embarked on a pioneering program to integrate the children of Liverpool who had been affected by Thalidomide into a mainstream school.
They are demanding action to address the increasing health needs of Thalidomide survivors and to help them seek justice against Grunenthal, the German manufacturer of the drug.
Steve, 54, from Selkirk in the Borders, and fellow Thalidomide campaigner Liz Buckle made a special trip to the Scottish Parliament to support mesh victims as they made their case to the Petitions Committee last Tuesday.
Starting in 2008, Marzia Lazzerini of the Institute for Maternal and Child Health in Trieste, Italy, and her colleagues randomly assigned 54 children with Crohn's to get daily thalidomide or a placebo.
In 1997 Diageo acquired Distillers Company, the Australian and New Zealand distributor of Thalidomide.