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(organic chemistry)
C7H8N4O2 A toxic alkaloid found in cocoa, chocolate products, tea, and cola nuts; closely related to caffeine.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



(3, 7-dimethylxanthine), an alkaloid of the purine group.

Theobromine is found in the beans of the cacao (Theobromacacao), where its content reaches 1.8 percent. It is a colorless crystalline substance with a bitter taste and only slight solubility in water. Theobromine is a spasmolytic and smooth muscle relaxant. It is used in medicine in cases of spasm of the blood vessels of the heart and brain, and also as a diuretic. Theobromine differs from caffeine, to which it is closely related in structure, in that its effect on the central nervous system is substantially less marked. Theobromine is obtained from cacao beans or is synthesized chemically. It is a constituent of Teofedrin and other compound preparations.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Kellogg, "Quantification of theobromine and caffeine in saliva, plasma and urine via liquid chromatography-tandem mass spectrometry: a single analytical protocol applicable to cocoa intervention studies," Journal of Chromatography B, vol.
She was given medication to reduce vomiting and stop her body absorbing theobromine.
Theobromine and caffeine are compounds found in chocolate, and many sugar-free or sugar substitute products contain xylitol.
Numerous studies have reported several significant bioactive groups in the cocoa and cocoa products including polyphenols (epicatechin, catechin and procyanidin) (Afoakwa et al., 2008; Arlorio et al., 2008; Ariza et al., 2014; Nsor-Atindana et al., 2012; Hii et al., 2009; Kim et al., 2014), methylxanthines (theobromine, caffein and theophylline) (Caudle et al., 2001; Mhd-Jalil and Ismail, 2008), peptides (albumins, globulins, prolamin, and glutenin) (Voight et al., 1993; Mhd-Jalil and Ismail, 2008) lipids and sterols (Schwan and Wheals, 2004; Lim, 2012), fiber (Paoletti et al., 2012) as well as minerals (magnesium, copper and selenium).
Theophylline, theobromine and caffeine existing in tea are among the type of methylxanthines that are found in almost all types of teas.
Samples of caffeine, theophylline, theobromine, spironolactone, propranolol, and ephedrine were supplied by Sigma (96 %).
The rich, highly concentrated cup of hot chocolate--almost with undetectable sugar content because of its high theobromine and thickened by egg yolks--showed the character of a good Filipino chocolate.
Chocolate is poisonous because it contains the methylxanthine theobromine, which is similar to caffeine and is used medicinally as a diuretic, heart stimulant, blood vessel dilator and a muscle relaxant.
About 300 people with a persistent cough are taking part in a clinical trial at 13 National Health Service hospitals in the UK where they are being given the naturally occurring chemical theobromine, derived from the raw ingredient of chocolate, twice a day for 14 days.
COMPOUND dog food made in Spain under the brand names Megazookit and Vitcan Total Actividad has more concentrated amounts of theobromine and caffeine than allowed in dog food.
Effect of cocoa and theobromine consumption on serum HDL-cholesterol concentrations: a randomized controlled trial.