thiazole

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thiazole

[′thī·ə‚zōl]
(organic chemistry)
C3H3NS A colorless to yellowish liquid with a pyridinelike aroma, slightly soluble in water, soluble in alcohol and ether; used as an intermediate for fungicides, dyes, and rubber accelerators.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The thiazol ring of epothilone A and the imidazol ring of H227 of bovine [beta]-tubulin are located in a face-to-face orientation (Figure 5B) (30).
In contrast, the [delta]-nitrogen atom of N227 in yeast tubulin can mimic the role of [delta]-nitrogen atom of histidine and makes hydrogen bond with thiazol ring of epothilone A (Figure 5B).
In addition to thiazoles, acetamide derivatives are already known for their stimulatory effect on the central nervous system [13].
Prompted by the aforementioned findings and in the continuation of our ongoing research on thiazoles (24) and pyrazolines (25) as cholinesterase inhibitors, we designed a new series of thiazolylpyrazoline derivatives based on the molecular hybridization of thiazole and pyrazoline scaffolds.
Gupta, "Thiazoles: having diverse biological activities," Medicinal Chemistry Research, vol.
Narasimhan, "Synthesis, molecular docking and QSAR studies of 2, 4-disubstituted thiazoles as antimicrobial agents," Journal of Applied Pharmaceutical Science, vol.
Attimarad, "Synthesis and evaluation of some substituted 2-arylamino coumarinyl thiazoles as potential NSAIDs," Asian Journal of Chemistry, vol.
Chand, "In[Cl.sub.3]-assisted, synthesis and cytotoxic studies of some novel heteroaryl thiazoles," International Journal of Chemical and Pharmaceutical Sciences, vol.
Thiazole and isothiazole derivatives have received and continue to receive considerable attention [1-2].The chemistry of thiazoles dates back to 1879 when benzothiazole came into light.
Thiazoles containing N=C-S moiety has been employed as antipsychotic [10] and antimalarial [11].
Analogously, acylation of amino thiazoles (1a-b) with a number of acid chlorides (7a-e) and with glutaric anhydride (9) afforded amides (8a-h) and carboxamide derivative (10), respectively, as shown in Scheme-2.