thiobarbiturate


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thiobarbiturate

[¦thī·ō·bär′bich·ə‚rāt]
(pharmacology)
A derivative of thiobarbituric acid that differs from the barbiturates in the replacement of one oxygen atom by sulfur but resembles the barbiturates in its effects.
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References in periodicals archive ?
This assay interference could be reproduced with thiopental added to control plasma and also with thiamylal (another thiobarbiturate) added to control plasma.
Thiourea and urea res idues containing thiobarbiturate and barbiturate analogs , res pectively, fas cinated s ubs tantial interes t due to their divers e biological activities like inhibition of collagenas e -3 (MMP-3) [10], matrix metalloproteinas es [11], and recombinant cytochrome P450 enzymes [12], methionine aminopeptidas e-1 (MetAP-1) [13].
Application of the thiobarbiturate assay to the measurement of lipid peroxidation products in microsomes.
"The only well-documented, breed-specific anesthetic drug concern is with the use of thiobarbiturates in Greyhounds," Dr.
Scharfe et al., "Binding free energy calculations and biological testing of novel thiobarbiturates as inhibitors of the human NA[D.sup.+] dependent histone deacetylase Sirt2," MedChemComm, vol.
As a result of pioneering work of Qin Yan, a novel series of 5-benzylidene thiobarbiturates (141) derivatives have been synthesized and screened for their antibacterial activity.