are useful intermediates in synthesis of heterocyclic compounds .
Table-1: Antioxidant/DPPH radical scavenging activity of 5-arylidene barbiturates and thiobarbiturates
This assay interference could be reproduced with thiopental added to control plasma and also with thiamylal (another thiobarbiturate
) added to control plasma.
Thiourea and urea res idues containing thiobarbiturate
and barbiturate analogs , res pectively, fas cinated s ubs tantial interes t due to their divers e biological activities like inhibition of collagenas e -3 (MMP-3) , matrix metalloproteinas es , and recombinant cytochrome P450 enzymes , methionine aminopeptidas e-1 (MetAP-1) .
Application of the thiobarbiturate
assay to the measurement of lipid peroxidation products in microsomes.
"The only well-documented, breed-specific anesthetic drug concern is with the use of thiobarbiturates
in Greyhounds," Dr.
Scharfe et al., "Binding free energy calculations and biological testing of novel thiobarbiturates
as inhibitors of the human NA[D.sup.+] dependent histone deacetylase Sirt2," MedChemComm, vol.
As a result of pioneering work of Qin Yan, a novel series of 5-benzylidene thiobarbiturates
(141) derivatives have been synthesized and screened for their antibacterial activity.