Thiobarbiturates are useful intermediates in synthesis of heterocyclic compounds [2].
Table-1: Antioxidant/DPPH radical scavenging activity of 5-arylidene barbiturates and
thiobarbiturates based derivatives
This assay interference could be reproduced with thiopental added to control plasma and also with thiamylal (another
thiobarbiturate) added to control plasma.
Thiourea and urea res idues containing
thiobarbiturate and barbiturate analogs , res pectively, fas cinated s ubs tantial interes t due to their divers e biological activities like inhibition of collagenas e -3 (MMP-3) [10], matrix metalloproteinas es [11], and recombinant cytochrome P450 enzymes [12], methionine aminopeptidas e-1 (MetAP-1) [13].
Application of the
thiobarbiturate assay to the measurement of lipid peroxidation products in microsomes.
"The only well-documented, breed-specific anesthetic drug concern is with the use of
thiobarbiturates in Greyhounds," Dr.
Scharfe et al., "Binding free energy calculations and biological testing of novel
thiobarbiturates as inhibitors of the human NA[D.sup.+] dependent histone deacetylase Sirt2," MedChemComm, vol.
As a result of pioneering work of Qin Yan, a novel series of 5-benzylidene
thiobarbiturates (141) derivatives have been synthesized and screened for their antibacterial activity.
