thioether


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thioether

[¦thī·ō′ē·thər]
(organic chemistry)
RSR A general formula for colorless, volatile organic compounds obtained from alkyl halides and alkali sulfides; the R groups can be the same, or different as in methylthioethane (CH3SC2H5).
References in periodicals archive ?
For instance, ADC with disulfide-linkage has been shown to have more cytotoxic activity than the same ADC with thioether linkage when they were directed to the tumor cell lines expressing a low copy number of targeted antigen (17).
As detailed in [19], [B.sub.2]T and [B.sub.4]T constructions were assembled by conjugation of a T-epitope N terminally elongated with Lys residues providing 2 or 4 levels of branching and functionalized with chloroacetyl units and an N-acetylated B epitope with a Cterminal Cys whose thiol group reacts with the chloroacetyl group to give a thioether link.
Zhu, Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents, Bioorg.
More specifically, lantibiotics are an important family of heat stable low molecular weight bacteriocins that possess unusual posttranslationally modified amino acids, such as lanthionine, methyllanthionine, dehydroalanine, and dehydrobutyrine with thioether linkages [2].
Fluensulfone or MCW-2, (5-chloro-2-(3,4,4-trifluorobut-3-enylsulfonyl)-1,3-thiazole is member of the fluoroalkenyl thioether group.
At first it is slowly and almost completely converted to 6-mercaptopourine (6-MP) by reductive cleavage of the thioether. This is mediated by glutathione and similar compounds in the intestinal wall, the liver and on red blood cells, without the aid of enzymes [7].
Studies about polymer based sulfonated proton exchange membrane materials such as poly(arylene ether sulfone)s [811], poly(ether ether ketone)s [12-14], poly(arylene thioether) [15-17], poly(phenylene)s [18-20], polyimides [21-24], and other types of polymers have largely taken place in the scope of polymer electrolyte membrane researches so far.
Identification of thioether intermediates in the reductive transformation of gonyautoxins into saxitoxins by thiols.
Kadcyla is an antibody-drug conjugate consisting of trastuzumab covalently linked to the microtubule inhibitor, DM1 (mertansine) via a non-reducible thioether linkage (MCC).
Chelation in metal intoxication XXVII: chelating agents containing vicinal thioether groups as antidotes of lead toxicity.
Prenylation is a type of lipid modification involving covalent addition of either farnesyl (15-carbon) or more commonly geranyl-geranyl (20-carbon) isoprenoids by thioether linkages to cysteine residues at or near the C terminus of intracellular proteins.
Clear transport selectivity for silver(I) ion was observed using both thioether donor macrocycles.