Thiopental Sodium

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thiopental sodium

[¦thī·ō′pen‚tal ′sōd·ē·əm]
(organic chemistry)
C11H17O2N2NaS Yellow, water-soluble crystals with a characteristic aroma; used in medicine as a short-acting anesthetic. Also known as thiopentone sodium.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Thiopental Sodium


(or Pentothal sodium), a medicinal preparation of the anesthetic group. It is mainly used for intravenous anesthesia and is prepared immediately before use. The antagonist of thiopental sodium is bemegride.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
(ii) The second batch will simultaneously receive thiopental sodium 40 mg/kg + bromazepam 30 mg/kg: this is the reference lot; the third batch will receive the product mixture 5a-d 100 mg/kg + 40 mg/kg of thiopental sodium: this is the batch of the product tested.
After 15 minutes, anaesthesia was induced with 2.5% Thiopental sodium (Thiosol Sodiumf) inj intravenously @ 12.5 mg/ kg b.
Intravenously administered valproate, diazepam and thiopental sodium are more successful, however at the cost of adverse effects.
It is not possible to administer so much of it that a lethal effect is guaranteed, but the substance is quite suitable for producing coma, after which termination may be effected using a muscle relaxant." (47) In the same article, the thiopental dose to be used was stated as, "intravenous administration of 1 g thiopental sodium, if necessary, 1.5-2 g of the product in case of strong tolerance to barbiturates." (48) Apparently the largest dose of thiopental used in the Netherlands was only 2 g (or 2000 mg) and it is therefore not surprising that such a dose was found to be less than 100% lethal.
Induction of anaesthesia was done with Thiopental sodium intravenously till effect and intubated with cuffed endotracheal tube.
Under general anesthesia "using Thiopental sodium in the dose of 50 mg/kg body weight" the trunk of radial nerve was sectioned in axilla on right side.
All dogs received an intramuscular injection of 0.02 mg/kg Atropine sulphate (a) before anaesthesia with intravenous Thiopental sodium (b) (@10 mg/ kg) 'to effect'.