The novel series of substituted 6-n-propyl thiouracils
was synthesized by Prachayasittikul et al.
Quercetin dihydrate, L-Thyroxine ([T.sub.4]), dithiothreitol (DTT), propyl thiouracil
(PTU) were purchased from Sigma Chemical Co., USA.
"Treatment of hyperthyroid with thiourea and thiouracil
." JAMA, 1943; 122:78-81.
Williams reported signs and symptoms of patients with known thyrotoxicosis who were being treated with thiouracil
. His study was not limited to new cases and was not intended to focus on presenting clinical manifestations.
Third investigation  showed that all investigated uracils interact hydrophobically with HRP heme group, but the measurements showed that only the thiouracil
derivatives 2-thiouracil and of 6-n-propyl-2-thiouracil inhibit HRP activity (noncompetitively).
In overt hyperthyroidism PTU (propyl thiouracil
) was given to the patient.
LPO: lipid peroxidation; MMP: mitochondrial membrane potential; HRP: horseradish peroxidase; PTU: 6-N-propyl-2- thiouracil
; NAC: N-acetylcysteine; Trolox: ([+ or -]}-6- hydroxy-2)5)7)8-tetramethylchroman-2-carboxylic acid; resveratrol: -trihydroxy-trans-stilbene; TEMPOL: 4-hydroxy- 2)2)6)6-tetramethylpiperidin-1-oxyl; DPPD: N,Nr-diphenyl-p- phenylenediamine.
The precipitate was filtered off, washed with [H.sub.2]O, and dried to give the corresponding thiouracil
Similar thyroid hyperplasia has been observed after treatment of fish with goitrogens such as thiourea and thiouracil
that inhibit coupling and formation of iodotyrosines in the thyroid.