thiouracil

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thiouracil

[′thī·ō′yu̇r·ə‚sil]

(pharmacology)

C₄H₄N₂OS A bitter-tasting white powder; used as an antithyroid drug that acts by interfering with thyroxine synthesis.

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The novel series of substituted 6-n-propyl thiouracils was synthesized by Prachayasittikul et al.

Significance and biological importance of pyrimidine in the microbial world

Quercetin dihydrate, L-Thyroxine ([T.sub.4]), dithiothreitol (DTT), propyl thiouracil (PTU) were purchased from Sigma Chemical Co., USA.

Annona squamosa seed extract in the regulation of hyperthyroidism and lipid-peroxidation in mice: possible involvement of quercetin

"Treatment of hyperthyroid with thiourea and thiouracil." JAMA, 1943; 122:78-81.

The safe and effective implementation of orthoiodosupplementation in medical practice

Williams reported signs and symptoms of patients with known thyrotoxicosis who were being treated with thiouracil. His study was not limited to new cases and was not intended to focus on presenting clinical manifestations.

Vomiting, nausea, and abdominal pain: unrecognized symptoms of thyrotoxicosis

Third investigation [30] showed that all investigated uracils interact hydrophobically with HRP heme group, but the measurements showed that only the thiouracil derivatives 2-thiouracil and of 6-n-propyl-2-thiouracil inhibit HRP activity (noncompetitively).

Inhibition of Horseradish Peroxidase Activity by Boroxine Derivative, Dipotassium-trioxohydroxytetrafluorotriborate [K.sub.2][[B.sub.3][O.sub.3][F.sub.4]OH]

In overt hyperthyroidism PTU (propyl thiouracil) was given to the patient.

Prevalance and fetomaternal outcome of thyroid disorder in pregnancy

LPO: lipid peroxidation; MMP: mitochondrial membrane potential; HRP: horseradish peroxidase; PTU: 6-N-propyl-2- thiouracil; NAC: N-acetylcysteine; Trolox: ([+ or -]}-6- hydroxy-2)5)7)8-tetramethylchroman-2-carboxylic acid; resveratrol: -trihydroxy-trans-stilbene; TEMPOL: 4-hydroxy- 2)2)6)6-tetramethylpiperidin-1-oxyl; DPPD: N,Nr-diphenyl-p- phenylenediamine.

Flutamide-induced cytotoxicity and oxidative stress in an in vitro rat hepatocyte system

The precipitate was filtered off, washed with [H.sub.2]O, and dried to give the corresponding thiouracil derivative 7.

Synthesis, single crystal X-ray structure, and antimicrobial activity of 6-(1,3-Benzodioxol-5-ylmethyl)-5-ethyl-2{[2-(morpholin-4-yl)ethyl]sulfanyl}pyrimidin-4(3H)-one

Similar thyroid hyperplasia has been observed after treatment of fish with goitrogens such as thiourea and thiouracil that inhibit coupling and formation of iodotyrosines in the thyroid.

Effects of ammonium perchlorate on thyroid function in developing fathead minnows, pimephales promelas