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The condition of having an abnormally small number of platelets in the circulating blood.



a decrease in the number of platelets to fewer than 200,000 per mm3 in the peripheral blood. It may result from the redistribution of platelets in the bloodstream or from hemorrhage. Other causes are the intensified loss of platelets associated with thrombocytopenic purpura, splenomegaly, disseminated intravascular thrombosis, and the use of certain drugs. Thrombocytopenia may also result from disturbance of platelet formation in the bone marrow in leukemia or aplastic anemia, and from ionizing radiation. Blood clotting is impaired in thrombocytopenia, resulting in a tendency of the mucous membranes to bleed, as well as in hemorrhaging and the appearance of petechiae in the internal organs. Bleeding usually becomes continuous when the platelet count falls below 20,000–30,000 per mm3 of blood. Therapy involves treatment of the underlying disease, administration of hemostatics, and transfusion of platelets.

References in periodicals archive ?
Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with or without thrombocytopenia.
Peripheral blood smear showed thrombocytopenia and leucopenia/neutropenia.
The diagnosis of heparin as a cause of thrombocytopenia (HIT) was missed at this point as heparin was no longer on the drug chart.
Laboratory evaluation typically reveals mild to moderate thrombocytopenia, unusually large platelets, and abnormal platelet function with absent or markedly reduced aggregation response to ristocetin.
This trial reports that prophylactic platelet transfusion is not superior to supportive care in the management of thrombocytopenia in adult dengue patients.
Febrile thrombocytopenia is commonly due to malaria, enteric fever, sepsis, leptospirosis, miliary tuberculosis, rickettsial infections, arbovirus such as dengue or yellow fever and human immunodeficiency virus (HIV).
Thrombocytopenia - Therapeutics under Development by Companies 14
Thrombocytopenia absent radius (TAR) syndrome is a rare genetic condition, characterized by bilateral absence of the radii while both thumbs are present, and thrombocytopenia.
We evaluated patients for a differential diagnosis of isolated severe thrombocytopenia.
Major cause of thrombocytopenia in ITP is accelerated platelet destruction and impaired platelet production.
The report provides a snapshot of the global therapeutic landscape of Thrombocytopenia