thrombolytic drug

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Related to thrombolytic therapy: thrombolytic drugs

thrombolytic drug

(thrŏm'bəlĭt`ĭk) or

clot-dissolving drug,

substance, such as streptokinase or tissue plasminogen activator (tPA), that causes the breakdown of blood clots (see thrombosisthrombosis
, obstruction of an artery or vein by a blood clot (thrombus). Arterial thrombosis is generally more serious because the supply of oxygen and nutrition to an area of the body is halted.
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) that obstruct the flow of blood through the vessels. Its uses include injection during or shortly after a heart attack or strokestroke,
destruction of brain tissue as a result of intracerebral hemorrhage or infarction caused by thrombosis (clotting) or embolus (obstruction in a blood vessel caused by clotted blood or other foreign matter circulating in the bloodstream); formerly called apoplexy.
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 (see infarctioninfarction,
blockage of blood circulation to a localized area or organ of the body resulting in tissue death. Infarctions commonly occur in the spleen, kidney, lungs, brain, and heart.
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) to prevent clots from blocking blood flow to the heart muscle or brain.
References in periodicals archive ?
After 90 minutes of reperfusion, the ECG- ST-elevation (reduction 50%) and pain reduction was used as criteria of reperfusion (zero hour) in the thrombolytic therapy status.
Under the premise that the patients' family members provided the disease history (no previous history of blood disorder, oral anticoagulant medication, or serious hepatonephric disease), the patients in group A were directly administered the rt-PA thrombolytic therapy without the results of blood clotting and hepatonephric function test, which saved at least 30 minutes and greatly shorten the interval between the onset to the thrombolytic therapy; therefore, more patients could be applied the thrombolytic therapy.19
Surgery versus thrombolytic therapy: In a meta-analysis and a systematic review by Castilho et al, surgery was compared with thrombolysis.
Creatine kinase MM and MB isoforms in patients receiving thrombolytic therapy and acute angiography.
Intravenous thrombolytic therapy is potentially an effective treatment of acute stroke, offering the possibility of early reperfusion of ischaemic cerebral tissue and limitation of infarct size.
Despite thrombolytic therapy, catheters can remain obstructed.
Repeat thrombolytic therapy was required in four patients and resulted in clinical success in all.
New anticoagulant drugs: the seventh ACCP conference on antithrombotic and thrombolytic therapy. Chest.2004;126:265S-287S.
"Thrombolytic therapy appears to be low risk and compatible with pregnancy, but the human pregnancy experience is limited.
The primary outcome measure was main pulmonary artery involvement; secondary outcomes were ICU admissions, emergency department mortality, and the use of thrombolytic therapy.
Apparently aimed at clinicians, this includes review and research studies on such topics as developments in screening for groups of syndromes across a large population base and thrombolytic therapy in patients with ventricular fibrillation.
The therapy with anticoagulants consist mainly of the use of standard or not fractioned heparin (HNF), low molecular weight heparins (HBPM) and thrombolytic therapy, with or without surgical intervention.