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Related to thromboplastin: Prothrombin time


see blood clottingblood clotting,
process by which the blood coagulates to form solid masses, or clots. In minor injuries, small oval bodies called platelets, or thrombocytes, tend to collect and form plugs in blood vessel openings.
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(Factor III), an important coagulation factor in the blood-clotting system; it helps convert prothrombin into thrombin. Thromboplastin is localized in the membranes of formed elements of the blood and in the cells of various organs. A large amount of thromboplastin enters the blood upon injury to tissues. Brain and lung tissues have especially high thrombo-plastic activity, and lung thromboplastin also takes part in the metabolism of the vasoactive polypeptides angiotensin and bradykinin.

Chemically, thromboplastin is a protein-lipid complex. The basis of its activity is its lipid constituent, which contains serine, eth-anolamine, and choline phosphatides. Blood coagulation factors are adsorbed on the phospholipid micelle, creating favorable conditions for the enzymatic reactions involved in blood clotting.

The term “thromboplastin” is sometimes used to designate an active complex that includes, in addition to thromboplastin, a number of protein factors and Ca2+ ions. Such active thromboplastin, which directly converts prothrombin into thrombin, is also called thrombokinase or prothrombinase. Thromboplastin is used in clinical practice to determine the prothrombin level, an indicator of the condition of the blood-clotting system.



Any of a group of lipid and protein complexes in blood that accelerate the conversion of prothrombin to thrombin. Also known as factor III; plasma thromboplastin component (PTC).
References in periodicals archive ?
A prospective study of the value of monitoring heparin treatment with the activated partial thromboplastin time.
As both Prothrombin time and Activated Partial Thromboplastin Time were deranged during hospital stay and at multiple times in the previous records, factor levels were sent.
One-Stage Prothrombin Time (PT) Test and Activated Partial Thromboplastin Time (APTT) Test; Approved Guideline H47-A2, 2nd edn.
aPTT, a modified version of the activated Partial Thromboplastin Time test, is a test that measures the intrinsic pathway of coagulation.
Purified thromboplastin causes haemostatic abnormalities but not overt DIC in an experimental rabbit model.
Activated partial thromboplastin time was measured using PTT STA reagent and anti-Xa activity was measured using Rotachrom reagent (detection limit 0.
Wounds from extremely sharp broadheads likely result in the deer releasing less thromboplastin.
Hence present study is undertaken to see the effect of type 2 diabetes on platelet aggregation, prothrombin time and activated partial thromboplastin time.
Assessment of coagulation status of patients was done using coagulation tests: activated partial thromboplastin time (APTT) and international normalized ratio (INR).
PE = pulmonary embolism, SD = standard deviation, INR = international normalised ratio, aPTT = activated partial thromboplastin time.
Coagulation studies showed that the prothrombin time, partial thromboplastin time, bleeding time, factor VIII, fibrinogen, D-dimer, anti-thrombin III, protein C, and S levels were normal.

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