thrombosis


Also found in: Dictionary, Thesaurus, Medical, Wikipedia.

thrombosis

(thrŏmbō`sĭs), obstruction of an artery or vein by a blood clot (thrombus). Arterial thrombosis is generally more serious because the supply of oxygen and nutrition to an area of the body is halted. Thrombosis of one of the arteries leading to the heart (heart attack; see infarctioninfarction,
blockage of blood circulation to a localized area or organ of the body resulting in tissue death. Infarctions commonly occur in the spleen, kidney, lungs, brain, and heart.
..... Click the link for more information.
) or of the brain (strokestroke,
destruction of brain tissue as a result of intracerebral hemorrhage or infarction caused by thrombosis (clotting) or embolus (obstruction in a blood vessel caused by clotted blood or other foreign matter circulating in the bloodstream); formerly called apoplexy.
..... Click the link for more information.
) can result in death and, in a vessel of the extremities, may be followed by gangrenegangrene,
local death of body tissue. Dry gangrene, the most common form, follows a disturbance of the blood supply to the tissues, e.g., in diabetes, arteriosclerosis, thrombosis, or destruction of tissue by injury.
..... Click the link for more information.
. Acute arterial thrombosis often results from the deposition of atherosclerotic material in the wall of an artery, which gradually narrows the channel, precipitating clot formation (see arteriosclerosisarteriosclerosis
, general term for a condition characterized by thickening, hardening, and loss of elasticity of the walls of the blood vessels. These changes are frequently accompanied by accumulations inside the vessel walls of lipids, e.g.
..... Click the link for more information.
). A thrombus that breaks off and circulates through the bloodstream is called an embolusembolus
, foreign matter circulating in and obstructing a blood vessel. It may be a portion of a clot that has separated from the wall of a vessel (see thrombosis), a bubble of gas or air (known as an air embolus), a globule of fat, a clump of bacterial matter, or a clump of
..... Click the link for more information.
.

Thrombosis

 

the formation of blood clots during life in the lumen of a blood vessel or in the heart.

Thrombogenesis is promoted by injury to the vascular wall owing to atherosclerosis or inflammation, by the slowing of the blood flow, and by an increase in the coagulability and viscosity of the blood. Peripheral venous thrombosis is most common; thrombosis in the arterial system occurs less frequently. Arterial thrombosis interferes with the blood supply to areas of tissue and often leads to necrosis of such tissue. For example, coronary thrombosis results in myocardial infarction, and cerebral thrombosis, in a stroke, or cerebrovascular accident. The thrombus may subsequently either dissolve (undergo lysis), with partial or complete restoration of the blood vessel’s patency, or it may become thickened (organized). Multiple capillary thrombosis, a syndrome involving disseminated intravascular blood coagulation, is often combined with an increased tendency for tissues to bleed. The condition may develop during shock, hemorrhage, or severe infectious diseases, or it may be a manifestation of intolerance for drugs.

Biochemical and roentgenological methods of examination are used to diagnose thrombosis. Treatment includes the administration of anticoagulants, antispasmodics, and fibrinolytic and anti-inflammatory agents, as well as surgical removal of the thrombus.

REFERENCES

Machabeli, M. S. Koagulopaticheskie sindromy. Moscow, 1970.
Kuznik, B. I., and V. P. Skipetrov. Formennye elementy krovi, sosudistaia stenka, gemostaz i tromboz. Moscow, 1974.
Raby, C. Lokalizovannaia i rasseiannaia vnutrisosudistaia koaguliatsiia. Moscow, 1974. (Translated from French.)
Quick, A. J. Hemorrhagic Diseases and Thrombosis, 2nd ed. Philadelphia, Pa., 1966.

A. N. SMIRNOV and V. D. TOPOLIANSKII

thrombosis

[thräm′bō·səs]
(medicine)
Formation of a thrombus.

thrombosis

1. the formation or presence of a thrombus
2. Informal short for coronary thrombosis
References in periodicals archive ?
It would be more appropriate to reevaluate the patient after thrombosis recovers and the blood levels reach the adult level (after the age of 6 months-1 year) (4, 8, 32).
Risk factors for superior ophthalmic vein thrombosis (SOVT) are multifactorial and include sinoorbital infections, autoimmune disorders (such as systemic lupus erythematosus, sarcoidosis, Behcet's syndrome, and Grave's disease), hypercoagulable states (such as pregnancy, use of oral contraceptive pills, sickle cell trait, and hereditary hemorrhagic telangiectasia), and systemic malignancies.
CT scan of the abdomen and pelvis with contrast (Figure 3) demonstrated ongoing cholecystitis with a resolving falciform ligament thrombosis. Laparoscopic cholecystectomy was carried out uneventfully and operative cholangiogram revealed no stones in the common bile duct (CBD).
Pulmonary vein thrombosis is a rare and potential life-threatening clinical entity that mainly occurs after thoracic surgery and lung transplantation [5].
This case demonstrates that prenatal diagnosis of umbilical artery thrombosis was a crucial step in avoiding possible serious adverse perinatal outcome [1-4].
Ultrasound diagnosis was a thrombosis of the renal vein with hypoperfusion of the renal artery.
Neurological involvement in BD occurs on average five years after the systemic findings are observed; it is observed 3-4 times higher in men than in women and the most common clinical presentation is sinus venous thrombosis at central nervous system (CNS) involvement; peripheral nerve or muscle involvement is very rare.
Contrast venography is considered the reference standard for the diagnosis of upper extremity thrombosis, but is infrequently performed due its invasive nature and the availability of noninvasive alternatives.
We present the case of a 29 year-old female patient, who developed during the 17th week of her second pregnancy an episode of superficial thrombophlebitis in the right external saphenous vein and the right popliteal vein, complicated in the 24th week with right ilio-femoral thrombosis, for which treatment with low molecular weight heparin (LMWH) was initiated.
Quantitative D-dimers and 3 risk stratification (Wells score) for deep venous thrombosis was done 24 hrs preoperatively 24 hrs, 72 hrs and 14 days postoperatively.
World Thrombosis Day is dedicated to educating people about the risk factors, signs, and symptoms of thrombosis.