thromboxane


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thromboxane

[‚thräm′bäk‚sān]
(biochemistry)
Any member of a group of 20-carbon fatty acids related to the prostaglandins and derived mainly from arachidonic acid.
References in periodicals archive ?
(1985) Isolation and characterization of thromboxane synthase from human platelets as a cytochrome P-450 enzyme.
Effect of onion and ginger consumption on platelet thromboxane production in humans.
Abe, "Rat kidney thromboxane receptor: Molecular cloning, signal transduction, and intrarenal expression localization," Journal of Clinical Investigation, vol.
Fei et al., "Association of thromboxane A2 receptor gene polymorphisms with cerebral infarction in a Chinese population," Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol.
Parratt, "AH23848, a thromboxane antagonist, suppresses ischaemia and reperfusion-induced arrhythmias in anaesthetized greyhounds," British Journal of Pharmacology, vol.
Kobayashi, "Interferon-a elevates pulmonary blood pressure in sheep--The role of thromboxane cascade," European Journal of Pharmacology, vol.
These larger platelets secrete more serotonin, b-thromboglobulin and thromboxane A2 as compared to comparatively smaller platelets13-16.
Oh-ishi, Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages, Biochemical and Biophysical Research Communication, 230(1), 110-114 (1997).
It occurs as a result of cold-induced cell death and development of localized inflammatory processes and tissue ischemia mediated by thromboxane A2, prostaglandin F2-alpha, bradykinins, and histamine (1).
One proposal was the prescription of acetylsalicylic acid in low doses (75-100 mg/day) to reduce inflammation and improve the balance between thromboxane A2/ prostacyclin.
Biomarkers analysed from both urine and plasma samples included cortisol (also analysed from saliva), substance P (SUBP), leukotriene B4 (LTB4), thromboxane B2 (Tbx-B2) and midkine.
In contrast to the traditional notion of "resistance" as an inherent or acquired defense or chemical blockage of a drug, whether by a microbe or the host, aspirin resistance may be either a laboratory-defined lack of inhibition of thromboxane A2, or a clinically defined entity.