Activation of the thromboxane
A2 pathway in human prostate cancer correlates with tumor Gleason score and pathologic stage.
The microfluidic assay brings together contributions of platelet collagen signaling, granule release, ADP signaling, thromboxane
synthesis, and adhesion strength under flow conditions.
Acute methionine load-induced hyperhomocysteinemia enhances platelet aggregation, thromboxane
biosynthesis, and macrophage-derived tissue factor activity in rats.
2] test measures a metabolite of serum thromboxane
58,63) This process leads to an increase in circulating tissue levels of various cytokines, (177-180) leukotrienes, (181) thromboxanes
, (182) platelet activating factor, (183) complement components, (184) elastases, and other enzymes, (185) and it causes the formation of additional ROS.
In fact, Simon et al (8) have shown in four phase II trials that celecoxib is effective in treating the signs and symptoms of osteoarthritis and rheumatoid arthritis, as well as showing that celecoxib is statistically significantly less likely than nonselective NSAIDs to cause gastric or duodenal erosions/ulcerations, (9) without any significant effect on platelet aggregation or thromboxane
2] (1 mM and 5 mM), ADP (5 [micro]M), and the thromboxane
A2 analog U46619 (1 [micro]M) were used as platelet agonists.
It plays a key role for the removal of harmful thrombotic agent because it provides a favourable ratio of prostacycli to thromboxane
, which reduce the risk of cardiovascular diseases.
However, in preeclampsia, this balance tips toward thromboxane
late in pregnancy.
The prostaglandins and thromboxane
identified were 6-keto-[PGF.
raises the risk of heart disease partly by constricting arteries.
levels and decreased platelet stickiness means less chance of developing a blood clot and therefore, less chance of a heart attack or stroke.