thymosin


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Thymosin

A polypeptide hormone synthesized and secreted by the endodermally derived reticular cells of the thymus gland. Thymosin exerts its actions in several loci: (1) in the thymus gland, either on precursor stem cells derived from fetal liver or from bone marrow, or on immature thymocytes, and (2) in peripheral sites, on either thymic-derived lymphoid cells or on precursor stem cells. The precursor stem cells, which are immunologically incompetent whether in the thymus or in peripheral sites, have been designated as predetermined T cells or T0 cells, and mature through stages termed T1 and T2, each reflecting varying degrees of immunological competence. Thymosin promotes or accelerates the maturation of T0 cells to T1 cells as well as to the final stage of a T2. In addition to this maturation influence, the hormone also increases the number of total lymphoid cells by accelerating the rate of proliferation of both immature and mature lymphocytes. See Immunity

thymosin

[′thī·mə·sən]
(immunology)
Any of a group of hormones secreted by the thymus gland that stimulate lymphocyte production within the thymus and confer on lymphocytes elsewhere in the body the capacity to respond to antigenic stimulation.
References in periodicals archive ?
Mice treated with thymosin beta-4 for a week before a heart attack produced a small number of new heart muscle cells, but mice given the drug only after a heart attack didn't.
Dr Paul Riley, of University College London, who led the research, said: "In the future if we can figure out how to direct the progenitor cells using thymosin beta 4, there could be potential for therapy based on the patients' own heart cells.
Thymosin beta-4 is already used in clinical trials to promote wound healing on the skin.
We share the excitement in the hepatitis research community about the potential of combination therapies such as thymosin alpha 1 plus interferon in the fight against hepatitis C.
Moreover, in 71 patients with classic NOS invasive ductal carcinomas, ProT [alpha] concentrations as assayed by a RIA that detects thymosin al were significantly greater in tumor samples than in normal breast tissue.
RegeneRx develops novel therapeutic peptides, including Thymosin beta 4 and its constituent fragments, for tissue and organ protection, repair and regeneration.
Drug development company RegeneRx Biopharmaceuticals (Other OTC:RGRX) reported on Monday the receipt of the notice of acceptance for a patent from the Australian Patent Office for the use of Thymosin beta 4 (T?
About RegeneRx - RegeneRx is focused on the development of a novel therapeutic peptide, Thymosin beta 4, or T?
Researchers report that thymosin beta 4 (TB4) can activate a unique subpopulation of resident adult epicardial stein cells to recapture embryonic potential, proliferate, migrate and differentiate into functional heart muscle cells, Rockville, Md.
Researchers report that thymosin beta 4 (TB4) can activate a unique subpopulation of resident adult epicardial stem cells to recapture embryonic potential, proliferate, migrate and differentiate into functional heart muscle cells, Rockville, Md.
Researchers added the synthetic peptide Thymosin beta 4 to a group of drug treatments - including statins - used for neurorestorative therapy to activate repair mechanisms, which mimic cellular changes that occur in the early stages of brain development.