In this study, we provide an alternative way to produce [N.sup.[alpha]]-terminal acetylated thymosin
a1 by cleaving the recombinant protein with legumain, which should be cheaper for large-scale production; as E.
Bae et al., "Thymosin
[beta]4 induces the expression of vascular endothelial growth factor (VEGF) in a hypoxia-inducible factor (HIF)-1[alpha]-dependent manner," Biochimica et Biophysica Acta (BBA)--Molecular Cell Research, vol.
White, "Preparation, assay, and partial purification of a thymic lymphocytopoietic factor (thymosin
)," Proceedings of the National Academy of Sciences of the United States of America, vol.
RegeneRx is focused on the development of a novel therapeutic peptide, Thymosin
beta 4, or TB4, for tissue and organ protection, repair and regeneration.
Wang et al., "MALAT-1, a novel noncoding RNA, and thymosin
beta4 predict metastasis and survival in early-stage non-small cell lung cancer," Oncogene, vol.
United States-based RegeneRx Biopharmaceuticals has enrolled the first patients in a phase three clinical trial (ARISE-2 trial) of RGN-259 (Thymosin
beta 4), a sterile, preservative-free eye drop formulation developed for patients with dry eye syndrome, neurotrophic keratopathy besides other corneal disorders, it was reported yesterday.
Gurel et al., "Thymosin
alpha 1 attenuates lipid peroxidation and improves fructose-induced steatohepatitis in rats," Clinical Biochemistry, vol.
The human thymus produces at least seven thymic proteins: thymopoietin, thymosin
alpha, thymulin, thymic humoral factor, hormonal thymic factor, serum thymic factor, and other thymic factors.
, containing thymic extracts, augments T-cell function and stimulates the production of interferons and interleukins [46,47].
M2 PHARMA-January 10, 2017-RegeneRx wins notice of acceptance of Australian patent for treatment of neural injury with Thymosin
[beta]4 (T[beta]4), although first described as a G-actin sequestering peptide regulating cytoskeletal rearrangement and cellular motility , has recently been shown to possess additional functions during cell fate determination and angiogenesis.