Animals, Animal Inflammation Model, Diet, Thymulin, and Inhibition of the NF-[kappa]B Cascade.
Thymulin solution (1.5 mg/kg) was injected intraperitoneally 1.5 hr before LPS treatment and was prepared from serum thymic factor (American Peptides, USA), to which an equimolar concentration of Zn[Cl.sub.2] was added .
The Effects of Thymulin and IKK Inhibitor XII on LPS-Treated Mice Immunity
Plasma Cytokines in LPS-Treated Mice Subjected to Thymulin and IKK Inhibitor XII.
Based on the above results, the optimal concentration of 20 mg/kg inhibitor was used in this experimental series examining the combined effect of thymulin with IKK Inhibitor XII.
In these experiments, we detected a significant increase in the concentration of IL-6 in LPS-treated mice, which was partly but not significantly decreased by pretreating the mice with IKK Inhibitor XII or with thymulin, demonstrating that these treatments could not completely ablate plasma IL-6 levels.
Thymulin (formerly called serum thymic factor) is a nonapeptide hormone secreted by human thymic epithelial cells and is essential for T-cell differentiation.
We confirmed this finding by determining serum thymulin concentrations in 5 patients, previously recruited for a prospective longitudinal analysis, (6) all of whom developed paradoxical TB-IRIS within 14 days of cART commencement.
(14) A quantitative measure of thymic function is achieved by assaying the nonapeptide hormone thymulin produced by thymic epithelial cells.
A zinc-dependent epitope on the molecule of thymulin, a thymic hormone.
The human thymus produces at least seven thymic proteins: thymopoietin, thymosin alpha, thymulin
, thymic humoral factor, hormonal thymic factor, serum thymic factor, and other thymic factors.