tight junction


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Related to tight junction: gap junction, Desmosomes, Adherens junction

tight junction

[¦tīt ′jəŋk·shən]
(cell and molecular biology)
An intercellular junction composed of a series of fusions of the junctional membrane, forming a continuous seal; serves as a selective barrier to small molecules and as a total barrier to large molecules. Also known as impermeable junction; occluding junction; zonula occludens.
References in periodicals archive ?
Consider probiotics, which may help reverse leaky gut by promoting tight junction proteins, though additional studies are still needed.
Bone-marrow mesenchymal stem cells reduce rat intestinal ischemia-reperfusion injury, ZO-1 downregulation and tight junction disruption via a TNF-a-regulated mechanism.
A previous high-scale analysis suggested a novel interacting protein that could associate to the nNOS PDZ domain: the tight junction protein Claudin-3 (Stiffler et al, 2007).
The short answer is by disrupting the epithelial cells themselves (transepithelial permeability) and by disrupting the spaces between the epithelial cells (paracellular permeability), which consist of tight junctions, the cytoskeleton, and several associated proteins (see figure below).
Relative protein levels of tight junction proteins in jejunal mucosa
2010), increasing the expression of epithelial tight junctions (Ma et al.
ATPase expression which in turn could regulate the function of trophectoderm tight junction.
Tight junction (TJ) proteins are essential components of blood-brain barrier (BBB) integrity [1, 2].
21,22) Claudins as a marker of tight junction, showed a pivotal role in morphogenesis and embryo development.
We are interested in two other types of cell adhesive channels, gap junction and tight junction channels.
Altered expression and localization of the tight junction protein ZO-1 in primary and metastatic pancreatic cancer.