tight junction


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Related to tight junction: gap junction, Desmosomes, Adherens junction

tight junction

[¦tīt ′jəŋk·shən]
(cell and molecular biology)
An intercellular junction composed of a series of fusions of the junctional membrane, forming a continuous seal; serves as a selective barrier to small molecules and as a total barrier to large molecules. Also known as impermeable junction; occluding junction; zonula occludens.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The gut microbiota is well known to support tight junction integrity between enterocytes.
Tricellulin deficiency affects tight junction architecture and cochlear hair cells.
The ZO-1, a tight junction protein necessary for pump function, expression can be detected in the bioengineered endothelium sheets.
Diosmectite-zinc oxide composite improves intestinal barrier function, modulates expression of pro-inflammatory cytokines and tight junction protein in early weaned pigs.
* Consider probiotics, which may help reverse leaky gut by promoting tight junction proteins, though additional studies are still needed.
La Torre et al., "Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease," Hepatology, vol.
The intestine being a highly regenerating organ, where intestinal epithelia rejuvenate every 3-7 days, we hypothesize that obesity-induced gut microbiome dysbiosis may be associated with the abnormalities in cellular turnover (i.e., cell death versus survival/proliferation) that impact gut permeability via modulation of tight junction and mucin formation.
Hu et al., "Connexin 43 gap junctions contribute to brain endothelial barrier hyperpermeability in familial cerebral cavernous malformations type III by modulating tight junction structure," The FASEB Journal, vol.