tissue plasminogen activator


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Related to tissue plasminogen activator: streptokinase

tissue plasminogen activator

[¦tish·ü plaz‚min·ə·jən ′ak·tə‚vād·ər]
(medicine)
A proteolytic enzyme that can convert plasminogen to plasmin.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Protective efficacy of a plasmid DNA encoding Japanese encephalitis virus envelope protein fused to tissue plasminogen activator signal sequences: studies in a murine intracerebral virus challenge model.
Loskutoff, "Kinetic analysis of the interactions between plasminogen activator inhibitor 1 and both urokinase and tissue plasminogen activator," Archives of Biochemistry and Biophysics, vol.
Does body weight influence the response to intravenous tissue plasminogen activator in stroke patients?
He provided sufficient data that recombinant tissue plasminogen activator is useful in treatment of acute ischemic stroke [68].
Thrombolysis in brain ischemia (TIBI) transcranial Doppler flow grades predict clinical severity, early recovery, and mortality in patients treated with intravenous tissue plasminogen activator. Stroke 2001; 32(1):89-93.
Human tissue plasminogen activator expression in Escherichia coli using cytoplasmic and periplasmic cumulative power.
The plasma concentration of total (TFPI-T) and free (TFPI-F) tissue factor pathway inhibitor-1, plasminogen activator inhibitor 1 (PAI-1), and tissue plasminogen activator (t-PA) were measured by standard sandwich ELISA technique using commercial kits (Diagnostica STAGO, R.C.S.
Recombinant tissue plasminogen activator (rtPA) in the treatment of cerebral ischemic stroke has been confirmed by American Food and Drug Administration (FDA) in 1996.7 In America, this drug causes symptoms improvement of stroke in more than 50% of cases with minimal serious complications.8 However, only 3 to 8.5% of patients were eligible for rtPA.9 Several studies about cost - effectiveness of this drug compared with the high cost and potential side effects of this drug have been performed.
Thrombolysis with recombinant tissue plasminogen activator (tPA, alteplase) is the only effective specific treatment for acute ischaemic stroke.