thromboplastin

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Related to tissue thromboplastin: Tissue factor

thromboplastin:

see blood clottingblood clotting,
process by which the blood coagulates to form solid masses, or clots. In minor injuries, small oval bodies called platelets, or thrombocytes, tend to collect and form plugs in blood vessel openings.
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Thromboplastin

 

(Factor III), an important coagulation factor in the blood-clotting system; it helps convert prothrombin into thrombin. Thromboplastin is localized in the membranes of formed elements of the blood and in the cells of various organs. A large amount of thromboplastin enters the blood upon injury to tissues. Brain and lung tissues have especially high thrombo-plastic activity, and lung thromboplastin also takes part in the metabolism of the vasoactive polypeptides angiotensin and bradykinin.

Chemically, thromboplastin is a protein-lipid complex. The basis of its activity is its lipid constituent, which contains serine, eth-anolamine, and choline phosphatides. Blood coagulation factors are adsorbed on the phospholipid micelle, creating favorable conditions for the enzymatic reactions involved in blood clotting.

The term “thromboplastin” is sometimes used to designate an active complex that includes, in addition to thromboplastin, a number of protein factors and Ca2+ ions. Such active thromboplastin, which directly converts prothrombin into thrombin, is also called thrombokinase or prothrombinase. Thromboplastin is used in clinical practice to determine the prothrombin level, an indicator of the condition of the blood-clotting system.

I. P. BASKOVA

thromboplastin

[‚thräm·bō′plas·tən]
(biochemistry)
Any of a group of lipid and protein complexes in blood that accelerate the conversion of prothrombin to thrombin. Also known as factor III; plasma thromboplastin component (PTC).
References in periodicals archive ?
In our lab, we came across a challenging situation when we switched to a new (for us) recombinant human tissue thromboplastin, which has an International Sensitivity Index (ISI) of around 1.
In the 1998 revision (H21-A3), CLSI removed the recommendation to use a discard tube when drawing PT (prothrombin time) and APTT (activated partial thromboplastin time) tests, since studies showed tissue thromboplastin did not affect results when the sodium citrate tube was the first or only tube drawn using a tube holder.
Some recommended procedures for acquiring samples for coagulation analysis, especially those involving the measurement of D-dimer and fibrinogen by the Clauss method, mandate that the first sample be discarded because tissue thromboplastin released by the trauma of venipuncture could interfere with coagulation assays by activating intrinsic pathway (2).