tolbutamide


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Related to tolbutamide: acarbose, metformin

tolbutamide

[täl′byüd·ə‚mīd]
(pharmacology)
C12H18N2O3S A hypoglycemic drug effective when administered orally.
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Abbreviations STZ streptozotocin OGTT oral glucose tolerance test CA cinnamic acid CD cinnamaldehyde GB glibenclamide TB tolbutamide BSA bovine serum albumin Db diabetic
Group I served as normal control and received distilled water, Group II served as diabetic control, Groups III-VI received the different extracts at a dose of 250 mg/kg body weight, and Group VII received standard drug tolbutamide (150 mg/kg b.
However, tolbutamide is exclusively hepatically metabolized and may be used in patients with CKD(American Society of Health-Systems Pharmacists, 2011c).
These results are comparable with the dose of Tolbutamide treated group also showed a significant fall of 26 per cent (P<0.
5) In a study using tolbutamide 500 mg as a CYP2C9 probe substrate, healthy subjects were CYP2C9*1 homozygotes, CYP2C9*1*2 heterozygotes, and CYP2C9*1*3 heterozygotes.
Next came metformin (32%), glyburide (13%), glipizide and gliclazide (7% each), tolbutamide (6%), and repaglinide (2%).
Normal rats, having undergone overnight fasting, received a single dose of 100 mg/kg or 200 mg/kg, while control groups received a placebo or tolbutamide 250 mg/kg.
The most commonly cited drugs in this category represent myeloablative chemotherapeutic compounds, such as alkylating agents, antimetabolites, and cytotoxic drugs, although certain antiviral agents, tolbutamide, and the thiazide diuretics have also been implicated.
ATP]-channel antagonist tolbutamide, and impaired responses to glucose (49, 50).
ATP] channels include levosimendan, nicorandil, cromakalim, diazoxide, minoxidil and pinacidil, while glibenclamide and tolbutamide both inhibit [K.
Ca-ATP channel is regulated by a sulfonylurea receptor and is inhibited by sulfonylurea compounds glibenclamide and tolbutamide.
In a double-blind, randomized study comparing Pterocarpus marsupium with the popular diabetes drug tolbutamide, 365 newly-diagnosed or untreated NIDDM patients were treated either with P.