tolbutamide


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Related to tolbutamide: acarbose, metformin

tolbutamide

[täl′byüd·ə‚mīd]
(pharmacology)
C12H18N2O3S A hypoglycemic drug effective when administered orally.
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Group Substance Category I 400 mg/kg of Tinospora juice (4 mL) Test II 250 mg/kg of Tolbutamide dissolved in Standard 4 mL distilled water III 4 mL distilled water Control Moderate Diabetes
Standard of phenacetin, tolbutamide, omeprazole, midazolam, and IS (1 mg/ml) were prepared by methanol.
The calibration curves of HPLC method were evaluated by analyzing a series of standard plasma samples at concentration from 0.2 to 200 [micro]g/ml for caffeine and from 0.4 to 400 [micro]g/ml for tolbutamide, chlorzoxazone, and midazolam.
After FA treatment, a cocktail solution of the different probe drugs (50 mg/mL phenacetin, 25 mg/mL tolbutamide, 50 mg/mL chlorzoxazone, and 50 mg/mL testosterone in 45% ethanol-saline solution) was injected intraperitoneally to all rats at a dose of 1.0 mL/kg.
The first generation of sulfonylureas are tolbutamide, tolazamide, and actohexamide and the second generation of sulfonylureas are glyburide, glipizide, gliclazide, glimepiride, and others.
However, these drugs themselves raise the gastric pH leading to the decrease in absorption of cefpodoxime, while increasing the absorption of [beta]-blockers and tolbutamide. [9] Drugs such as ketoconazole, fluconazole, methotrexate, clopidogrel, paroxetine, and diazepam require acidic medium for their optimal absorption.
Tolbutamide can be obtained by the isosteric replacement of NH 2 by CH 3 group in carbutamide.
Geraldes, "Molecular modelling and 1H-NMR: ultimate tools for the investigation of tolbutamide: [beta]-cyclodextrin and tolbutamide: hydroxypropyl-[beta]-cyclodextrin complexes," Chemical and Pharmaceutical Bulletin, vol.
Hypoglycemic agents, e.g., insulin, tolbutamide, phenformin, troglitazone, rosigitazone and repaglinide, are the mainstay of diabetes treatments and are effective in controlling hyperglycemia.
Group VII: Diabetic rats administered with tolbutamide (150 mg/kg b.w.) in aqueous solution orally for 28 days.