Trials also showed the mycologie and clinical cure rates of naftifine 2% to be equivalent or superior to those of terbinafine, econazole, clotrimazole, miconazole, and tolnaftate
In systematic reviews of available placebo-controlled trials, 1% tolnaftate
was shown to be less effective against tinea pedis than the azoles and allylamines, with a number needed to treat of 3.6 for tinea pedis (LOE=1a).
TABLE RECOMMENDED TOPICAL TREATMENTS FOR TINEA PEDIS Cure Frequency Bates, and duration Drug % Form of treatment * Comments Miconazole 47 2% lotion, BID for 2-4 Inexpensive, (Micatin) spray, weeks OTC cream, powder Terbinafine 70 1% cream, BID for 1-2 Shorter length (Lamisil) solution, weeks of treatment, spray OTC Naftifine 70 1% gel, QD for 2-4 Once a day, Rx (Naftin) cream weeks Butenafine 70 1% cream QD for 4 Once a day, Rx (Mentax) weeks Tolnaftate
64 1% powder, BID for 2-4 Inexpensive, (Tinactin, spray, cream weeks OTC Altate) Rx denotes prescription; OTC, over the counter; BID, twice a day; QD, every day.
Also, Fougera's Consumer Products division has launched over-the-counter TipTapToe tolnaftate
solution (a version of Tinactin) in a new, more convenient delivery vehicle.
The products are formulated with tolnaftate
, a widely used antifungal ingredient, and include tea tree oil for its soothing properties.
Other anti-itch products use such active ingredients as clotrimazole (Schering-Plough Corp.'s Lotrimin) and tolnaftate
formula plus tolnaftate
, an approved ingredient for preventing and curing athlete's foot.
is marketing Tolnaftate
, a generic version of Schering-Plough's Tinactin, and Miconazole, a generic equivalent of Johnson & Johnson's Micatin antifungal cream.